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Tyrphostins inhibit lipopolysaccharide induced preterm labor in mice
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J. E. Mijovic
Published/Copyright:
June 1, 2005
Abstract
Objective: We tested whether lipopolysaccharide (LPS)-induced murine preterm birth was delayed by tyrphostins (inhibitors of tyrosine kinases).
Study design: The tyrphostins, AG126 or AG1288, or the prostaglandin endoperoxide H synthase-2 (PGHS-2) inhibitor, NS-398, were administered 2 h before LPS, with LPS, or 2 h after LPS and their effect on gestational length was measured.
Results: Only tyrphostins and NS-398 administered 2h before LPS successfully delayed preterm birth (p < 0.05).
Conclusions: Both tyrphostins AG126 and AG1288 as well as NS-398 inhibited LPS induced preterm birth to the time of normal birth.
:
Published Online: 2005-06-01
Published in Print: 2002-07-26
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Taurine and taurine-deficiency in the perinatal period
- The effect of betamethasone administration to pregnant women on maternal serum indicators of infection
- Chorioamnionitis: Elevated interleukin-6 and interleukin-8 concentrations in the lower uterine segment
- Tyrphostins inhibit lipopolysaccharide induced preterm labor in mice
- Amniotic fluid matrix metalloproteinase-8 and the development of cerebral palsy
- Echocardiographic screening for congenital heart disease: a randomized study
- Maternal obesity not maternal glucose values correlates best with high rates of fetal macrosomia in pregnancies complicated by gestational diabetes
- Increased endothelial thrombomodulin (TM) expression in pregnancies complicated by IUGR
- Serum amyloid A protein in the early detection of late-onset bacterial sepsis in preterm infants
- Carbon dioxide levels do not predict duration of home oxygen requirement: a retrospective study
- A congenital anterior diaphragmatic hernia with massive pericardial effusion requiring neither emergency pericardiocentesis nor operation. A case report and review of the literature
- Extravascular collection of fluid around the vertebra resulting from malpositioning of a peripherally inserted central venous catheter in extremely low birth weight infants
- Placental boost to varicella-zoster antibodies in the newborn
- Enhancing decision-making by depressed pregnant patients
- Congress Calendar
- WAPM-Newsletter No 2/2002
