Effect of amino acids on glucose tolerance and hyperkalemia in very low birth weight infants
-
S. DeSilva
Abstract
Objective: The purpose of the study was to investigate alimentation of very low birth weight (VLBW) infants and its effect on blood concentration of glucose, urea nitrogen, creatinine and potassium.
Methods: The subjects were 100 VLBW infants born between 1993–1999. The gestational age ranged from 23 to 32 weeks and the birth weight from 443 to 1470 g. Intravenous glucose infusions were begun shortly after birth, amino acids on day 3 and lipids on day 4. Blood samples were drawn for determinations of urea nitrogen, creatinine and potassium.
Results: Mean caloric intake of glucose rose from 24.7 kcal/kg/day on day 1 to 58.1 kcal/kg/day on day 8 (p < 0.0001) and of amino acids from 1.1 g/kg/day on day 3 to 1.9 g/kg/day on day 8 (p < 0.0001). Potassium administration increased from 1 mq/kg/day on day 2 to 1.9 mq/kg/day on day 8. Urea nitrogen was at a mean level of 21.4 mg/dl on day 4 and declined afterwards (p < 0.0001). Serum potassium levels declined from 5.9 mmol/L on day 2 to 4.1 mmol/L on day 8 (p < 0.0001), while creatinine levels remained stable.
Conclusion: Our findings suggest that a catabolic state in VLBW infants begins to be reversed when the caloric intake of 40–50 kcal/kg/day is achieved.
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Vitamin A supplementation ameliorates butyric acid-induced intestinal mucosal injury in newborn rats
- Effect of amino acids on glucose tolerance and hyperkalemia in very low birth weight infants
- Steroidogenesis patterns in common trisomies
- A weighted risk index for antenatal prediction of perinatal outcome
- Acute side effects of surfactant treatment
- Neonatal sepsis of nosocomial origin: an epidemiological study from the "Grupo de Hospitales Castrillo"
- Ischemic reperfusion brain injury in fetal transgenic mice with elevated levels of copper-zinc superoxide dismutase
- Neonatal hyperbilirubinemia and Gilbert's syndrome
- Prenatal diagnosis and postnatal outcome of cardiac rhabdomyomas
- HPA-1 carrier status and thrombocytopenia in preterm infants with a birth weight below 1500 grams
- Sacrococcygeal teratoma. Outcome and management. An analysis of 17 cases
- Treatment of severe cholestasis in neonatal Dubin-Johnson syndrome with ursodeoxycholic acid
- Urinary bladder perforation in a very low birth weight infant. A case report
- Book review
- Congress Calendar
