HPA-1 carrier status and thrombocytopenia in preterm infants with a birth weight below 1500 grams
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W. Göpel
Abstract
Objective: In cohorts of infants with proven neonatal alloimmune thrombocytopenia (NAIT) an unusual high rate of preterm infants has been reported, raising the question of whetherNAIT contributes to the high rate of intracranial hemorrhage in preterm infants.
Methods: We genotyped the HPA-1-allele in a large cohort of term (n = 205) and very low birth weight infants (VLBW-infants, n = 299) with polymerase-chain-reaction and restriction enzyme digestion.
Results: HPA-1a/b is the only fetal HPA-1-genotype in which alloimmunization and NAIT could occur. Genotype distribution did not differ between term and VLBW-infants (p = 0.26). Furthermore, neither HPA-1a/b genotype nor platelet count at birth were of significant prognostic value in predicting subsequent intracranial haemorrhage or death inVLBW-infants (p = 0.93 and p = 0.19 respectively).
Conclusion: Our data did not support the hypothesis that routine screening of preterm infants or their mothers for HPA-1-genotype is of additional value in the care of these infants.
Copyright (c) 2002 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Vitamin A supplementation ameliorates butyric acid-induced intestinal mucosal injury in newborn rats
- Effect of amino acids on glucose tolerance and hyperkalemia in very low birth weight infants
- Steroidogenesis patterns in common trisomies
- A weighted risk index for antenatal prediction of perinatal outcome
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- Ischemic reperfusion brain injury in fetal transgenic mice with elevated levels of copper-zinc superoxide dismutase
- Neonatal hyperbilirubinemia and Gilbert's syndrome
- Prenatal diagnosis and postnatal outcome of cardiac rhabdomyomas
- HPA-1 carrier status and thrombocytopenia in preterm infants with a birth weight below 1500 grams
- Sacrococcygeal teratoma. Outcome and management. An analysis of 17 cases
- Treatment of severe cholestasis in neonatal Dubin-Johnson syndrome with ursodeoxycholic acid
- Urinary bladder perforation in a very low birth weight infant. A case report
- Book review
- Congress Calendar
