Maternal serum interleukin 6 levels in preterm labor: prediction of admission-to-delivery interval
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Nilgün Öztürk Turhan
Abstract
Objective: To evaluate the diagnostic value of maternal serum interleukin 6 (IL-6), C-reactive protein (CRP) levels and white blood cell (WBC) count for the prediction of preterm labor and length of admission-to-delivery interval in patients with preterm labor.
Methods: Maternal serum IL-6, CRP and WBC count were prospectively determined in eighty-two patients in preterm labor and 21 controls. Data was analyzed in study and control groups, and for the assessment of clinical and laboratory risk factors in the prediction of admission-to-delivery interval in the study group.
Results: Maternal serum IL-6 levels were significantly higher in the study group than controls. The IL-6 value associated with the highest percent of true positives and true negatives for the prediction of preterm labor was 5 pg/ml. The area under curve of maternal IL-6 was significantly higher than the area under curve of of CRP and WBC count. In the study group maternal serum IL-6 levels were significantly higher in patients delivered within 2 and 7 days than the nondelivering ones and a cut off value of 8.3 pg/ml was determined for estimation of preterm delivery.
Conclusion: Maternal serum IL-6 is a reliable marker in the prediction and management of preterm labor and delivery.
Copyright (c)2000 by Walter de Gruyter GmbH & Co. KG
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Artikel in diesem Heft
- Fetal venous circulation - an update on hemodynamics
- Soluble intercellular adhesion molecule and C-reactive protein as early markers of infection in newborns
- Risk factors for intraventricular hemorrhage in a birth cohort of 3721 premature infants
- Choice of cesarean section and perception of legal pressure
- Detection of C-type natriuretic peptide in fetal circulation
- Evaluation of a strategy to limit blood donor exposure in high risk premature newborns based on clinical estimation of transfusion need
- The significance of interleukin-6 concentrations in cervicovaginal fluid: its relation to umbilical cord plasma and the influence of antibiotic treatment
- Maternal serum interleukin 6 levels in preterm labor: prediction of admission-to-delivery interval
- Extracellular matrix components of the wall of umbilical cord vein and their alterations in pre-eclampsia
- Legionnaires disease complicating pregnancy: a case report with intrauterine fetal demise
- Intrauterine MRI with single-shot fast-spin echo imaging showed different signal intensities in hypoplastic lungs
- Congenital lobar emphysema occurring in twins
- Fetal intrathoracic injuries following mild maternal motor vehicle accident
