Abstract
Background: Severe acquired hypothyroidism often results in significant height deficit due to rapid bone age advancement following treatment. Whether gradual correction of hypothyroidism and/or adjunctive growth-promoting therapies (GPTs) augment final adult height (FAH) is controversial.
Objective: To investigate time to euthyroidism, pace of bone age advancement (ΔBA/ΔCA), and impact of GPTs on FAH.
Methods and patients: Retrospective review of 21 children (10.1±3.0 years) with profound hypothyroidism.
Results: Baseline bone age standard deviation score (SDS) was –4.1±1.8, whereas height SDS was –3.0±1.1. Average time to euthyroidism was 9.7 months (2.3–33.7 months). Average ΔBA/ΔCA was 2.3±0.9. Six of 13 patients at FAH received GPTs. No correlation was found between time to euthyroidism and rate of skeletal maturation. No difference in height outcome was seen between those who received GPTs and those who did not.
Conclusions: Neither time to euthyroidism nor use of GPTs significantly affected height potential in our patients.
©2011 by Walter de Gruyter Berlin Boston
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- Meetings
- Meetings Calendar
Articles in the same Issue
- Editorial
- Intracranial cysts: large-scale information is needed
- Reviews
- The endocrine spectrum of intracranial cysts in childhood and review of the literature
- Radioiodine treatment in pediatric Graves disease and thyroid carcinoma
- Images in Pediatric Endocrinology
- Perineal ectopic testis: a rare cause of empty scrotum
- Original Articles
- Normal thyroid function in young adults who were born very preterm
- Does clinical management impact height potential in children with severe acquired hypothyroidism?
- Neurodevelopment of preterm infants born at 28 to 36 weeks of gestational age: the role of hypothyroxinemia and long-term outcome at 4 years
- Central hypothyroidism following chemotherapy for acute lymphoblastic leukemia
- The prevalence of non-alcoholic fatty liver disease and metabolic syndrome in obese children
- Retinol binding protein 4 is associated with adiposity-related co-morbidity risk factors in children
- Circulating adipocyte fatty acid-binding protein, juvenile obesity, and metabolic syndrome
- Obesity and associated cardiovascular risk factors among schoolchildren in Greece: a cross-sectional study and review of the literature
- Peptides from adipose tissue in monitoring energy balance in infants
- Effectiveness of pentoxifylline on the cross-sectional area of intima media thickness and functions of the common carotid artery in adolescents with type 1 diabetes
- Common adipokine features of neonates and centenarians
- Congenital adrenal hyperplasia: as viewed by parents of affected children in India – a pilot study
- Characteristics and prevalence of non-classical congenital adrenal hyperplasia with a V281l mutation in patients with premature pubarche
- Contribution of bone turnover markers to bone mass in pubertal boys and girls
- Modifiable factors associated with low bone mineral content in underprivileged premenarchal Indian girls
- Effect of GnRH analogue on height potential in patients with severe growth hormone insensitivity syndrome treated with IGF-I
- Measurement of amino-terminal propeptide of C-type natriuretic peptide in patients with idiopathic short stature or isolated growth hormone deficiency
- Growth hormone treatment, final height, insulin-like growth factors, ghrelin, and adiponectin in four siblings with Seckel syndrome
- Health promotion intervention in Arab-Israeli kindergarten children
- Validation of automatic bone age rating in children with precocious and early puberty
- Interrelationship of carpal angle and bone age in children of different generations: a retrospective study
- Clinical characteristics of recessive and dominant congenital hyperinsulinism due to mutation(s) in the ABCC8/KCNJ11 genes encoding the ATP-sensitive potasium channel in the pancreatic beta cell
- Use of nocturnal melatonin concentration and urinary 6-sulfatoxymelatonin excretion to evaluate melatonin status in children with severe sepsis
- Primary ovarian dysfunction after hematopoietic stem cell transplantation during childhood: busulfan-based conditioning is a major concern
- Vitamin D status and insulin requirements in children and adolescent with type 1 diabetes
- Patient Reports
- Homozygosity for two missense mutations in the leptin receptor gene (P316T;W646C) in a Turkmenian girl with severe early-onset obesity
- A 3-year-old girl with Graves’ disease with hypoglycemia following transient adrenal hyporesponsiveness
- Papillary carcinoma masquerading as clinically toxic adenoma in very young children
- Hyperandrogenism in a set of triplets with modification of clinical course by hyperthyroidism
- A case of Langerhans cell histiocytosis with thyroid involvement
- Congenital rhabdomyosarcoma, central precocious puberty, hemihypertrophy and hypophosphatemic rickets associated with epidermal nevus syndrome
- Precocious puberty and empty sella syndrome in a girl cured of acute lymphoblastic leukemia
- Sex of rearing seems to exert a powerful influence on gender identity in the absence of strong hormonal influence: report of two siblings with PAIS assigned different sex of rearing
- Transient neonatal diabetes with two novel mutations in the KCNJ11 gene and response to sulfonylurea treatment in a preterm infant
- Persistent hypoglycemia caused by umbilical arterial catheterization
- Congestive heart failure as an initial manifestation of reninoma
- Multiple pterygium syndrome: mimicking the findings of Turner syndrome
- A neonate with contiguous deletion syndrome in XP21
- Kocher-Debré-Sémélaigne syndrome with pericardial effusion
- Meetings
- Meetings Calendar