Different progestins in the treatment of endometriosis – are there relevant differences?
-
Karl-Werner Schweppe
Abstract
Oral progestins without an estrogen component have been described to be effective in the treatment of endometriosis. Several different substances have been tested, which are on the one hand derivatives of the natural progesterone or of the C-17-OH-progesteron, or on the other hand derivatives of C-19-nortestosteron. Their common characteristic is the secretory transformation of estrogen primed uterine endometrium for which different dosages are necessary because of their different biological activities. They are different with regard to their profile and potency of action on hypothalamicpituitary axis, metabolic processes, breast tissue and genital organs. They are effectively similar with regard to endometriosis related complaints if sufficient doses are administered. No effects are noted on reduced fertility in endometriotic patients and the data are inconsistent concerning direct effects on the endometriotic cells.
©2010 by Walter de Gruyter Berlin New York
Artikel in diesem Heft
- Editorial
- Biological responses of progestogen metabolites in normal and cancerous human breast
- Mechanisms for differential effects between natural progesterone and synthetic progestogens on normal breast tissue
- Antigonadotropic progestogens as contraceptive agents in women with contraindication to combined pill
- Progestogen effects at vascular level: the endothelial cells
- Progestogens for treatment and prevention of pregnancy disorders
- Dysfunctional uterine bleeding: from adolescence to menopause
- Progestin effects in endometriosis treatment: new research on mechanisms
- Different progestins in the treatment of endometriosis – are there relevant differences?
- Progesterone, progestins and psychosomatic health of women
Artikel in diesem Heft
- Editorial
- Biological responses of progestogen metabolites in normal and cancerous human breast
- Mechanisms for differential effects between natural progesterone and synthetic progestogens on normal breast tissue
- Antigonadotropic progestogens as contraceptive agents in women with contraindication to combined pill
- Progestogen effects at vascular level: the endothelial cells
- Progestogens for treatment and prevention of pregnancy disorders
- Dysfunctional uterine bleeding: from adolescence to menopause
- Progestin effects in endometriosis treatment: new research on mechanisms
- Different progestins in the treatment of endometriosis – are there relevant differences?
- Progesterone, progestins and psychosomatic health of women
