Article
Licensed
Unlicensed
Requires Authentication
Laboratory assessment of new anticoagulants
-
Meyer M. Samama
and
Céline Guinet
Published/Copyright:
February 3, 2011
Abstract
With the introduction of new anticoagulant agents, there is a need for information on which coagulation tests are most suitable. These agents react differently to assays used to monitor older anticoagulant agents because they have alternative modes of action. Therefore, other tests, or modifications of existing tests which are more appropriate for newer agents, are needed. The prothrombin time test (with conversion to the international normalized ratio) is usually used to monitor warfarin. However, conversion to the international normalized ratio is not appropriate for measuring the effects of fondaparinux, dabigatran, rivaroxaban or apixaban. Instead, chromogenic assays, one-step prothrombinase-induced clotting time test and the HepTest with reduced incubation time, are among the different or modified tests that appear to give the most reproducible and accurate results. The tests show variations in response to anticoagulants – some of which have clinical relevance. Thus, it is important to be aware of the observed variations in order to prevent the misinterpretation of test results.
Received: 2010-9-14
Accepted: 2010-12-6
Published Online: 2011-02-03
Published in Print: 2011-05-01
©2011 by Walter de Gruyter Berlin New York
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Editorials
- Laboratory testing and/or monitoring of the new oral anticoagulants/antithrombotics: for and against?
- Circulating macrocomplexes: old wine in new bottles?
- Review
- Laboratory assessment of new anticoagulants
- Minireviews
- Biomarkers in Alzheimer’s disease
- Analytical variability in sport hematology: its importance in an antidoping setting
- The plodding diagnosis of monogenic autoinflammatory diseases in childhood: from the clinical scenery to laboratory investigation
- Opinion Paper
- Collective opinion paper on findings of the 2010 convocation of experts on laboratory quality
- Genetics and Molecular Diagnostics
- Genetic variability of the fructosamine 3-kinase gene in diabetic patients
- Identification of Bcl-2/IgH fusion sequences using real-time PCR and chip-based microcapillary electrophoresis
- Performance evaluation of a multiplex assay for future use in biomarker discovery efforts to predict body composition
- Pharmacogenetics of tacrolimus after renal transplantation: analysis of polymorphisms in genes encoding 16 drug metabolizing enzymes
- General Clinical Chemistry and Laboratory Medicine
- Quality Indicators in Laboratory Medicine: from theory to practice
- Implementation of computerized add-on testing for hospitalized patients in a large academic medical center
- Human growth hormone (GH) immunoassay: standardization and clinical implications
- Coagulation assays based on the Luminescent Oxygen Channeling Immunoassay technology1)
- Trefoil factor family peptides in human saliva and cyclical cervical mucus. Method evaluation and results on healthy individuals
- Steroid binding properties of the 2nd WHO International Standard for sex hormone-binding globulin
- Thyroxin overdose due to rheumatoid factor interferences in thyroid-stimulating hormone assays
- Cancer Diagnostics
- Quantification of HER2 autoantibodies in the amplification phenomenon of HER2 in breast cancer
- Glycosylation of proteins in healthy and neoplastic human salivary glands – a preliminary study
- Infectious Diseases
- Quantification of cerebrospinal fluid lactic acid in the differential diagnosis between HIV chronic meningitis and opportunistic meningitis
- Cardiovascular Diseases
- Carotid restenosis is associated with plasma ADMA concentrations in carotid endarterectomy patients
- High concentrations of asymmetric dimethylarginine are associated with ST-segment resolution failure after reperfusion for acute myocardial infarction
- An increase in serum uric acid concentrations is associated with an increase in the Framingham risk score in Korean adults
- The effect of a one-year weight reduction program on serum uric acid in overweight/obese children and adolescents
- False positive troponin result caused by a true macrotroponin
- Letters to the Editor
- Patient safety: patient identification wristband errors
- Prevalence of hemolytic specimens referred for arterial blood gas analysis
- “Triage” of lymphoid malignancies in the peripheral blood using the Extended Immunofluorescent Application of the CELL-DYN Sapphire automated hematology analyzer
- Presepsin (sCD14-ST): development and evaluation of one-step ELISA with a new standard that is similar to the form of presepsin in septic patients
Articles in the same Issue
- Editorials
- Laboratory testing and/or monitoring of the new oral anticoagulants/antithrombotics: for and against?
- Circulating macrocomplexes: old wine in new bottles?
- Review
- Laboratory assessment of new anticoagulants
- Minireviews
- Biomarkers in Alzheimer’s disease
- Analytical variability in sport hematology: its importance in an antidoping setting
- The plodding diagnosis of monogenic autoinflammatory diseases in childhood: from the clinical scenery to laboratory investigation
- Opinion Paper
- Collective opinion paper on findings of the 2010 convocation of experts on laboratory quality
- Genetics and Molecular Diagnostics
- Genetic variability of the fructosamine 3-kinase gene in diabetic patients
- Identification of Bcl-2/IgH fusion sequences using real-time PCR and chip-based microcapillary electrophoresis
- Performance evaluation of a multiplex assay for future use in biomarker discovery efforts to predict body composition
- Pharmacogenetics of tacrolimus after renal transplantation: analysis of polymorphisms in genes encoding 16 drug metabolizing enzymes
- General Clinical Chemistry and Laboratory Medicine
- Quality Indicators in Laboratory Medicine: from theory to practice
- Implementation of computerized add-on testing for hospitalized patients in a large academic medical center
- Human growth hormone (GH) immunoassay: standardization and clinical implications
- Coagulation assays based on the Luminescent Oxygen Channeling Immunoassay technology1)
- Trefoil factor family peptides in human saliva and cyclical cervical mucus. Method evaluation and results on healthy individuals
- Steroid binding properties of the 2nd WHO International Standard for sex hormone-binding globulin
- Thyroxin overdose due to rheumatoid factor interferences in thyroid-stimulating hormone assays
- Cancer Diagnostics
- Quantification of HER2 autoantibodies in the amplification phenomenon of HER2 in breast cancer
- Glycosylation of proteins in healthy and neoplastic human salivary glands – a preliminary study
- Infectious Diseases
- Quantification of cerebrospinal fluid lactic acid in the differential diagnosis between HIV chronic meningitis and opportunistic meningitis
- Cardiovascular Diseases
- Carotid restenosis is associated with plasma ADMA concentrations in carotid endarterectomy patients
- High concentrations of asymmetric dimethylarginine are associated with ST-segment resolution failure after reperfusion for acute myocardial infarction
- An increase in serum uric acid concentrations is associated with an increase in the Framingham risk score in Korean adults
- The effect of a one-year weight reduction program on serum uric acid in overweight/obese children and adolescents
- False positive troponin result caused by a true macrotroponin
- Letters to the Editor
- Patient safety: patient identification wristband errors
- Prevalence of hemolytic specimens referred for arterial blood gas analysis
- “Triage” of lymphoid malignancies in the peripheral blood using the Extended Immunofluorescent Application of the CELL-DYN Sapphire automated hematology analyzer
- Presepsin (sCD14-ST): development and evaluation of one-step ELISA with a new standard that is similar to the form of presepsin in septic patients
