Article
Licensed
Unlicensed
Requires Authentication
Evaluation of the accuracy of serum human epididymis protein 4 in combination with CA125 for detecting ovarian cancer: a prospective case-control study in a Korean population
-
Yong Man Kim
,
Joonseok Park
Published/Copyright:
February 15, 2011
Abstract
Background: This study aimed to determine the serum concentrations of CA125 and human epididymis protein 4 (HE4) in patients with ovarian cancer, and to evaluate the sensitivity and specificity of these biomarkers for differentiating between patients with benign gynecological disease and those with ovarian cancer, when used alone and in combination in a Korean population.
Methods: We consecutively recruited 159 women with an adnexal mass, including 78 women with ovarian cancer. A total of 224 healthy women served as controls. The serum concentrations of HE4 and CA125 were analyzed using immunochemiluminescence assays. The concentrations of the markers were compared among the different subgroups, and the diagnostic accuracy of each marker and the combination of the two markers was assessed by plotting receiver operating characteristic (ROC) curves. In addition, the Risk of Ovarian Malignancy Algorithm (ROMA) was utilized to categorize patients into low- and high-risk groups for epithelial ovarian cancer.
Results: Serum HE4 and CA125 concentrations were significantly higher in the ovarian cancer patients compared with those seen in patients with benign disease or in the healthy controls (p<0.0001 in both). In patients with an adnexal mass, the area under the ROC curve was higher when the combination of the markers was used compared with use of CA125 only. Using ROMA, patients could be successfully classified into high- and low-risk group, with 87.5% sensitivity at a specificity of 93.8%.
Conclusions: These findings suggest that measuring serum HE4 concentrations along with CA125 concentrations may provide higher accuracy for detecting ovarian cancer.
Received: 2010-10-29
Accepted: 2011;-1-10
Published Online: 2011-02-15
Published in Print: 2011-03-01
©2011 by Walter de Gruyter Berlin New York
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Editorial
- Biomarkers of neurodegenerative diseases
- Reviews
- CSF biomarkers in neurodegenerative diseases
- Tau and p-tau as CSF biomarkers in dementia: a meta-analysis
- Amyloid β (Aβ) and phospho-tau (p-tau) as diagnostic biomarkers in Alzheimer's disease
- The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease
- Advanced glycation endproducts as gerontotoxins and biomarkers for carbonyl-based degenerative processes in Alzheimer's disease
- Parkinson's disease – the continuing search for biomarkers
- α-Synuclein in Parkinson disease and other neurodegenerative disorders
- S100B protein in neurodegenerative disorders
- Inflammatory and structural biomarkers in acute traumatic spinal cord injury
- Homocysteine: a biomarker in neurodegenerative diseases
- Editorial
- ROMA or death: advances in epithelial ovarian cancer diagnosis
- Review
- Laboratory testing for the antiphospholipid syndrome: making sense of antiphospholipid antibody assays
- General Clinical Chemistry and Laboratory Medicine
- Quality indicators and specifications for key analytical-extranalytical processes in the clinical laboratory. Five years’ experience using the Six Sigma concept
- Determination of oxidative and occupational stress in palliative care workers
- Effect of cigarette smoking on plasma homocysteine concentrations
- Erythrocyte membrane protein analysis by sodium dodecyl sulphate-capillary gel electrophoresis in the diagnosis of hereditary spherocytosis
- Evaluation of hematological parameters on admission for the prediction of 7-day in-hospital mortality in a large trauma cohort
- Platelet function testing in hirudin and BAPA anticoagulated blood
- Evaluation of the iChem® Velocity™ Urine Chemistry Analyzer in a hospital routine laboratory
- Crystalluria: prevalence, different types of crystals and the role of infrared spectroscopy
- Cancer Diagnostics
- The ROMA (Risk of Ovarian Malignancy Algorithm) for estimating the risk of epithelial ovarian cancer in women presenting with pelvic mass: is it really useful?
- Evaluation of the accuracy of serum human epididymis protein 4 in combination with CA125 for detecting ovarian cancer: a prospective case-control study in a Korean population
- Cardiovascular Diseases
- APOA5 −1131T/C polymorphism is associated with coronary artery disease in a Chinese population: a meta-analysis
- Assessment of the nickel-albumin binding assay for diagnosis of acute coronary syndrome
- Letters to the Editor
- AGER gene -374T>A (rs1800624) polymorphism is not associated with the severity of non-diabetic coronary artery disease in Han Chinese
- Some lessons learned from using medium scale genotyping techniques in pharmacogenetic research
- Improved neopterin ELISA kit: a good compromise between HPLC results and clinical practice
- Cross-reactivity of 25-hydroxy vitamin D2 from different commercial immunoassays for 25-hydroxy vitamin D: an evaluation without spiked samples
- Modulated human maternal and premature neonatal erythrocyte membrane enzyme activities in relation to the mode of delivery: in vitro restoration with L-Carnitine
Articles in the same Issue
- Editorial
- Biomarkers of neurodegenerative diseases
- Reviews
- CSF biomarkers in neurodegenerative diseases
- Tau and p-tau as CSF biomarkers in dementia: a meta-analysis
- Amyloid β (Aβ) and phospho-tau (p-tau) as diagnostic biomarkers in Alzheimer's disease
- The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease
- Advanced glycation endproducts as gerontotoxins and biomarkers for carbonyl-based degenerative processes in Alzheimer's disease
- Parkinson's disease – the continuing search for biomarkers
- α-Synuclein in Parkinson disease and other neurodegenerative disorders
- S100B protein in neurodegenerative disorders
- Inflammatory and structural biomarkers in acute traumatic spinal cord injury
- Homocysteine: a biomarker in neurodegenerative diseases
- Editorial
- ROMA or death: advances in epithelial ovarian cancer diagnosis
- Review
- Laboratory testing for the antiphospholipid syndrome: making sense of antiphospholipid antibody assays
- General Clinical Chemistry and Laboratory Medicine
- Quality indicators and specifications for key analytical-extranalytical processes in the clinical laboratory. Five years’ experience using the Six Sigma concept
- Determination of oxidative and occupational stress in palliative care workers
- Effect of cigarette smoking on plasma homocysteine concentrations
- Erythrocyte membrane protein analysis by sodium dodecyl sulphate-capillary gel electrophoresis in the diagnosis of hereditary spherocytosis
- Evaluation of hematological parameters on admission for the prediction of 7-day in-hospital mortality in a large trauma cohort
- Platelet function testing in hirudin and BAPA anticoagulated blood
- Evaluation of the iChem® Velocity™ Urine Chemistry Analyzer in a hospital routine laboratory
- Crystalluria: prevalence, different types of crystals and the role of infrared spectroscopy
- Cancer Diagnostics
- The ROMA (Risk of Ovarian Malignancy Algorithm) for estimating the risk of epithelial ovarian cancer in women presenting with pelvic mass: is it really useful?
- Evaluation of the accuracy of serum human epididymis protein 4 in combination with CA125 for detecting ovarian cancer: a prospective case-control study in a Korean population
- Cardiovascular Diseases
- APOA5 −1131T/C polymorphism is associated with coronary artery disease in a Chinese population: a meta-analysis
- Assessment of the nickel-albumin binding assay for diagnosis of acute coronary syndrome
- Letters to the Editor
- AGER gene -374T>A (rs1800624) polymorphism is not associated with the severity of non-diabetic coronary artery disease in Han Chinese
- Some lessons learned from using medium scale genotyping techniques in pharmacogenetic research
- Improved neopterin ELISA kit: a good compromise between HPLC results and clinical practice
- Cross-reactivity of 25-hydroxy vitamin D2 from different commercial immunoassays for 25-hydroxy vitamin D: an evaluation without spiked samples
- Modulated human maternal and premature neonatal erythrocyte membrane enzyme activities in relation to the mode of delivery: in vitro restoration with L-Carnitine
