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Ischemia modified albumin changes – review and clinical implications

  • Eftihia Sbarouni EMAIL logo , Panagiota Georgiadou and Vassilis Voudris
Published/Copyright: November 18, 2010
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Clinical Chemistry and Laboratory Medicine
From the journal Clinical Chemistry and Laboratory Medicine Volume 49 Issue 2

Abstract

Ischemia modified albumin (IMA), as measured using the albumin cobalt binding test, is currently the most promising biomarker for early detection of ischemia before the onset of irreversible cardiac injury. This paper reviews the information available on IMA, including its pathophysiology, analysis, clinical applications and future perspectives. The data provided was identified by a search of MEDLINE using the terms IMA, biomarkers and ischemia. IMA may be useful to cover the complete diagnostic window of patients presenting with acute coronary syndromes (ACS) in the Emergency Department, along with the electrocardiogram and cardiac troponins. Preliminary data regarding the significance of IMA in the prognosis of either ACS or following revascularization need further study.

Keywords: biomarkers; ischemia; ischemia modified albumin
Corresponding author: Eftihia Sbarouni, 2nd Department of Cardiology, Onassis Cardiac Surgery Center, 356 Syngrou Avenue, 176 74 Athens, Greece Phone: +30 210 9493372, Fax: +30 210 9493373
Received: 2010-7-12
Accepted: 2010-8-25
Published Online: 2010-11-18
Published in Print: 2011-02-01

©2011 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2011.037
Keywords for this article
biomarkers; ischemia; ischemia modified albumin

Articles in the same Issue

  1. Editorial
  2. Hepcidin: the main regulator of iron homeostasis
  3. Reviews
  4. Global trends in critical values practices and their harmonization
  5. Ischemia modified albumin changes – review and clinical implications
  6. Genetics and Molecular Diagnostics
  7. Decreased serum brain-derived neurotrophic factor (BDNF) is associated with post-stroke depression but not with BDNF gene Val66Met polymorphism
  8. A novel liquidchip platform for simultaneous detection of 70 alleles of DNA somatic mutations on EGFR, KRAS, BRAF and PIK3CA from formalin-fixed and paraffin-embedded slides containing tumor tissue
  9. General Clinical Chemistry and Laboratory Medicine
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  12. The quality of the extra-analytical phase of laboratory practice in some developing European countries and Mexico – a multicentric study
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  15. Urinary stone composition in pediatric patients: a retrospective study of 205 cases
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  22. A new tool in the field of in-vitro diagnosis of allergy: preliminary results in the comparison of ImmunoCAP© 250 with the ImmunoCAP© ISAC
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