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Carcinoembryonic antigen concentrations in patients with acute coronary syndrome
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Cristina Vassalle
Published/Copyright:
July 7, 2010
Abstract
Background: Carcinoembryonic antigen (CEA), one of the most widely used tumor markers, has been recently associated with carotid atherosclerosis. The aim of our study was to evaluate whether CEA concentrations have a role in coronary artery disease (CAD).
Methods: Serum CEA concentrations were evaluated in 89 patients, including 50 patients with acute coronary syndrome (ACS) (Group I, 44 with acute myocardial infarction, six with unstable angina, 38 males, 65±2 years) and 39 patients with stable CAD (Group II, 33 males, 66±3 years). In addition, 33 subjects (16 males, 62±2 years) were also included as a control group (Group III).
Results: ACS was significantly associated with increased mean CEA concentrations (3.1±0.3 vs. 1.75±0.1 and 1.7± 0.2 ng/mL in Groups I, II and III, respectively, p<0.001). Increased CEA concentrations remained an independent determinant for ACS (OR=3.1, 95% CI=1.2–7.9, p<0.05) after correcting for other significant risk factors.
Conclusions: CEA might represent a potential new candidate biomarker for the prediction of risk associated with ACS.
Clin Chem Lab Med 2010;48:1339–43.
Keywords: acute coronary syndrome; atherosclerosis; carcinoembryonic antigen; risk factors; tumor markers
Received: 2009-12-29
Accepted: 2010-3-5
Published Online: 2010-07-07
Published in Print: 2010-09-01
©2010 by Walter de Gruyter Berlin New York
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Keywords for this article
acute coronary syndrome;
atherosclerosis;
carcinoembryonic antigen;
risk factors;
tumor markers
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