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Gender does not influence cystatin C concentrations in healthy volunteers
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Letícia Schwerz Weinert
Veröffentlicht/Copyright:
18. Dezember 2009
Abstract
Background: Current data are conflicting about the influence of gender on cystatin C concentrations. The goal of this study was to determine the reference interval for serum cystatin C in normal Brazilian subjects, taking into account the influence of gender.
Methods: Ninety-seven healthy volunteers, aged 18–70 years, 44% male, had glomerular filtration rate (GFR) measured using a 51Cr-EDTA method and estimated with the Modification of Diet in Renal Disease (MDRD) study equation. Serum cystatin C was measured using a turbidimetric method, and creatinine by the Jaffe method.
Results: Mean serum cystatin C was not significantly different between males and females, 0.62±0.12 vs. 0.65±0.12 mg/L, respectively (p=0.26). However, median serum creatinine was significantly higher in men [97 (80–115) vs. 80 (53–88) μmol/L; p=0.0001]. There were also no significant differences between genders with respect to GFR measured using 51Cr-EDTA (103±14 for males and 106±19 mL/min/1.73 m2 for females, p=0.47), and estimated with the MDRD equation (86±12 vs. 83±16 mL/min/1.73 m2, respectively, p=0.24).
Conclusions: There was no effect of gender on serum cystatin C, as well as on measured and estimated GFR.
Clin Chem Lab Med 2010;48:405–8.
Keywords: creatinine; cystatin C; glomerular filtration rate; Modification of Diet in Renal Disease; 51Cr-EDTA
Received: 2009-7-13
Accepted: 2009-11-3
Published Online: 2009-12-18
Published in Print: 2010-03-01
©2010 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
creatinine;
cystatin C;
glomerular filtration rate;
Modification of Diet in Renal Disease;
51Cr-EDTA
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- Minireview
- Standardization in clinical enzymology: a challenge for the theory of metrological traceability
- Review
- Laboratory reporting of hemostasis assays: the final post-analytical opportunity to reduce errors of clinical diagnosis in hemostasis?
- Opinion Paper
- The underestimated problem of using serum magnesium measurements to exclude magnesium deficiency in adults; a health warning is needed for “normal” results
- Genetics and Molecular Diagnostics
- Integrated PCR amplification and detection processes on a Lab-on-Chip platform: a new advanced solution for molecular diagnostics
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