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Proteomics in protein misfolding diseases
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Monica Stoppini
Published/Copyright:
June 1, 2009
Abstract
Protein misfolding and deposition as amyloid, with consequent tissue damage, plays a key role in the group of diseases generically termed amyloidoses. In the systemic forms, amyloid deposition is widespread and causes severe dysfunction of vital organs. Proteomic analysis, thanks to its versatility and the comprehensiveness of information obtained, is an ideal tool for the study of systemic amyloidoses. It has been successfully employed in the characterization of the circulating amyloidogenic precursors and the analysis of affected tissues, for the diagnostic identification of the fibril components and for characterizing disease-related changes in protein expression. We present the developments in the field of proteomics applied to systemic amyloidoses, and discuss the perspectives opened in the study of these diseases.
Clin Chem Lab Med 2009;47:627–35.
Received: 2009-2-15
Accepted: 2009-4-20
Published Online: 2009-06-01
Published in Print: 2009-06-01
©2009 by Walter de Gruyter Berlin New York
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- A focus on recent advances in proteomics – one step closer to entrance into the clinical arena
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- Proteomics in protein misfolding diseases
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- Proteomics of exhaled breath: methodological nuances and pitfalls
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- Increased CA 19-9 level in patients without malignant disease
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