Artikel
Lizenziert
Nicht lizenziert
Erfordert eine Authentifizierung
Risk loci for type 2 diabetes – Quo vadis?
-
Rob N.M. Weijers
Veröffentlicht/Copyright:
9. Februar 2009
Abstract
Reduced insulin sensitivity plays a role in the early pathogenesis of type 2 diabetes, and defects in insulin secretion by pancreatic β-cells are instrumental in hyperglycemic progression. There is strong evidence that genetic factors play an important role in both of these components. Several of the single nucleotide polymorphisms (SNPs) of genes associated with an increased risk of type 2 diabetes are hypothesized to influence β-cell function. The aim of the present study was to describe the function of the latter genes, to analyze the implications of the SNP positions within or near these genes, and to evaluate the suggested primary role of pancreatic β-cells in the etiology of type 2 diabetes.
Clin Chem Lab Med 2009;47:383–6.
Keywords: genome-wide association study; mitochondrion; pancreatic β-cell function; single nucleotide polymorphism; type 2 diabetes
Received: 2008-10-21
Accepted: 2008-12-9
Published Online: 2009-02-09
Published in Print: 2009-04-01
©2009 by Walter de Gruyter Berlin New York
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Artikel in diesem Heft
- Minireview
- Risk loci for type 2 diabetes – Quo vadis?
- Genetics and Molecular Diagnostics
- A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females. Czech post-MONICA and 3PMFs studies
- Genotype distribution of estrogen receptor α polymorphisms in pregnant women from healthy and preeclampsia populations and its relation to blood pressure levels
- Do common genetic variants in endotoxin signaling pathway contribute to predisposition to alcoholic liver cirrhosis?
- The selection and application of ssDNA aptamers against MPT64 protein in Mycobacterium tuberculosis
- Stromal cell-derived factor-1 but not its receptor, CXCR4, gene variants increase susceptibility and pathological development of hepatocellular carcinoma
- Expression of lineage markers using real-time quantitative polymerase chain reaction (RT-qPCR) in normal and in leukemia bone marrow
- Translation termination and protein folding pathway genes are not correlated in gastric cancer
- General Clincial Chemistry and Laboratory Medicine
- Novel serum paraoxonase activity assays are associated with coronary artery disease
- Elevated erythrocyte carbonic anhydrase activity is a novel clinical marker in hyperventilation syndrome
- Elevation of the glycoxidation product Nε-(carboxymethyl)lysine in patients presenting with acute myocardial infarction
- Lipoprotein(a) level and its association with tumor stage in male patients with primary lung cancer
- A high-performance liquid chromatography method for the determination of carbamazepine and carbamazepine-10,11-epoxide and its comparison with chemiluminescent immunoassay
- Reference Values and Biological Variations
- Minimizing the effects of multicollinearity in the polynomial regression of age relationships and sex differences in serum levels of pregnenolone sulfate in healthy subjects
- Determination of physiological plasma pentraxin 3 (PTX3) levels in healthy populations
- Validation and Outcome Studies
- Analytical precision of the Urolizer® for the determination of the BONN-Risk-Index (BRI) for calcium oxalate urolithiasis and evaluation of the influence of 24-h urine storage at moderate temperatures on BRI
- Determination of nitrotyrosine concentrations in plasma samples of diabetes mellitus patients by four different immunoassays leads to contradictive results and disqualifies the majority of the tests
- Estimation of trueness of measurement results obtained in external quality assessment
- Letters to the Editor
- A new PCR-RFLP assay for –1123 G>C polymorphism in the PTPN22 gene: allele and genotype frequencies in a western Mexican population
- Proposed classification of various limit values (guide values) used in assisting the interpretation of quantitative laboratory test results
- Case report: Over-substitution of thyroxine due to interference in serum thyroid-stimulating hormone measurement
- Rv2629 191A/C nucleotide change is not associated with rifampicin resistance in Mycobacterium tuberculosis
Schlagwörter für diesen Artikel
genome-wide association study;
mitochondrion;
pancreatic β-cell function;
single nucleotide polymorphism;
type 2 diabetes
Artikel in diesem Heft
- Minireview
- Risk loci for type 2 diabetes – Quo vadis?
- Genetics and Molecular Diagnostics
- A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females. Czech post-MONICA and 3PMFs studies
- Genotype distribution of estrogen receptor α polymorphisms in pregnant women from healthy and preeclampsia populations and its relation to blood pressure levels
- Do common genetic variants in endotoxin signaling pathway contribute to predisposition to alcoholic liver cirrhosis?
- The selection and application of ssDNA aptamers against MPT64 protein in Mycobacterium tuberculosis
- Stromal cell-derived factor-1 but not its receptor, CXCR4, gene variants increase susceptibility and pathological development of hepatocellular carcinoma
- Expression of lineage markers using real-time quantitative polymerase chain reaction (RT-qPCR) in normal and in leukemia bone marrow
- Translation termination and protein folding pathway genes are not correlated in gastric cancer
- General Clincial Chemistry and Laboratory Medicine
- Novel serum paraoxonase activity assays are associated with coronary artery disease
- Elevated erythrocyte carbonic anhydrase activity is a novel clinical marker in hyperventilation syndrome
- Elevation of the glycoxidation product Nε-(carboxymethyl)lysine in patients presenting with acute myocardial infarction
- Lipoprotein(a) level and its association with tumor stage in male patients with primary lung cancer
- A high-performance liquid chromatography method for the determination of carbamazepine and carbamazepine-10,11-epoxide and its comparison with chemiluminescent immunoassay
- Reference Values and Biological Variations
- Minimizing the effects of multicollinearity in the polynomial regression of age relationships and sex differences in serum levels of pregnenolone sulfate in healthy subjects
- Determination of physiological plasma pentraxin 3 (PTX3) levels in healthy populations
- Validation and Outcome Studies
- Analytical precision of the Urolizer® for the determination of the BONN-Risk-Index (BRI) for calcium oxalate urolithiasis and evaluation of the influence of 24-h urine storage at moderate temperatures on BRI
- Determination of nitrotyrosine concentrations in plasma samples of diabetes mellitus patients by four different immunoassays leads to contradictive results and disqualifies the majority of the tests
- Estimation of trueness of measurement results obtained in external quality assessment
- Letters to the Editor
- A new PCR-RFLP assay for –1123 G>C polymorphism in the PTPN22 gene: allele and genotype frequencies in a western Mexican population
- Proposed classification of various limit values (guide values) used in assisting the interpretation of quantitative laboratory test results
- Case report: Over-substitution of thyroxine due to interference in serum thyroid-stimulating hormone measurement
- Rv2629 191A/C nucleotide change is not associated with rifampicin resistance in Mycobacterium tuberculosis
