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CTLA-4 polymorphism 49A–G is associated with placental abruption and preeclampsia in Finnish women
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Ester Jääskeläinen
Published/Copyright:
December 13, 2007
Abstract
Background: Our aim was to study genetic variability in the gene encoding cytotoxic T-lymphocyte antigen (CTLA-4) and individual susceptibility to the development of preeclampsia or placental abruption.
Methods: A total of 361 women (132 with preeclampsia, 117 with placental abruption and 112 healthy controls) were genotyped for 49A–G polymorphism (dbSNP: rs231775) in the CTLA-4 gene.
Results: The frequency of the G alleles was significantly higher in women with preeclampsia than in controls (51.1% vs. 42.0%; OR 1.44, 95% CI 1.01–3.48, p<0.043). Women with placental abruption had decreased frequency of AA genotype (22.2% vs. 35.7%) and significantly more AG or GG genotypes compared with controls (OR 1.94, 95% CI 1.09–2.07, p<0.024). No significant differences were detected in the frequencies of genotype GG (29.5%, 21.4% and 19.6%, respectively) between the three groups.
Conclusions: Our data suggest that the 49A–G polymorphism in the CTLA-4 gene is associated with the development of placental abruption and preeclampsia, with women having the G allele being at risk.
Clin Chem Lab Med 2008;46:169–73.
Keywords: cytotoxic T-lymphocyte antigen (CTLA-4); placental abruption; preeclampsia; pregnancy; 49A–G polymorphism; Thr17Ala polymorphism
Received: 2007-5-25
Accepted: 2007-9-22
Published Online: 2007-12-13
Published in Print: 2008-02-01
©2008 by Walter de Gruyter Berlin New York
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Keywords for this article
cytotoxic T-lymphocyte antigen (CTLA-4);
placental abruption;
preeclampsia;
pregnancy;
49A–G polymorphism;
Thr17Ala polymorphism
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