Relationship between serum uric acid, creatinine, albumin and gestational diabetes mellitus
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Emre Sinan Güngör
Abstract
Background: During normal pregnancy, plasma concentrations of creatinine and uric acid normally decrease as a consequence of their increased glomerular filtration. Hyperuricemia in pregnant women has been associated with several pregnancy complications. We researched the relationship between serum uric acid, creatinine and albumin levels in pregnant women with normal glucose tolerance and gestational diabetes mellitus.
Methods: A total of 112 patients were evaluated, 56 of whom had gestational diabetes. All of the patients had single estimations of serum uric acid, creatinine, albumin and liver enzymes carried out on booking between the 24th and 28th gestational weeks. The women were followed up throughout pregnancy.
Results: Significant differences were found between the two groups for maternal age, gravida, parity and maternal weight gain during pregnancy, but not for body mass index or blood pressure. Creatinine levels were significantly higher in the diabetic group than in the control group [0.6±0.15 vs. 0.43±0.1 mg/dL (53.04±13.26 μmol/L vs. 38.01±8.84 μmol/L), p<0.001]. Uric acid levels were also higher in the diabetic patients, but this elevation was not statistically significant [4.42±1.09 vs. 4.1±0.84 mg/dL (260.78±64.31 μmol/L vs. 241.49±49.56 μmol/L), p>0.05]. There were no differences in mean albumin concentrations or liver function tests.
Conclusions: In this prospective study of Turkish women, we found that patients with gestational diabetes had significantly higher levels of creatinine than normal pregnant women.
Clin Chem Lab Med 2006;44:974–7.
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©2006 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Laboratory medicine in the 2000s: programmed death or rebirth?
- Polymorphisms of the inflammatory system and risk of ischemic cerebrovascular events
- Haptoglobin polymorphism in patients with preeclampsia
- Fifteen polymorphisms in endothelin-1, endothelin-2 and endothelin-receptor-A genotyped by four duplex assays and seven simple assays on a LightCycler using hybridization probes
- Optimization of an enzymatic method for the determination of lysosomal N-acetyl-β-D-hexosaminidase and β-glucuronidase in synovial fluid
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- Aminothiols in human brain tumors
- Measurement of carnitine in hemodialysis patients – adaptation of an enzymatic photometric method for an automatic analyzer
- A robust liquid chromatography tandem mass spectrometry method for total plasma homocysteine determination in clinical practice
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- Influence of the needle bore size used for collecting venous blood samples on routine clinical chemistry testing
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- Evaluation of the analytical performance of the advanced method for cardiac troponin I for the AxSYM platform: comparison with the old method and the Access system
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- Guidelines for setting up an External Quality Assessment Scheme for blood smear interpretation. Part II: survey preparation, statistical evaluation and reporting
- Free light chain testing in follow-up of multiple myeloma
- Blood reactive oxygen metabolites (ROMs) and total antioxidant status (TAS) in patients with laryngeal squamous cell carcinoma after surgical treatment
- SIBioC 2006 38th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology, Turin, Italy, September 19–22, 2006
- Third Santorini Biologie Prospective Conference 2006: From Human Genetic Variations to Prediction of Risks and Responses to Drugs and the Environment, Santorini Island, Greece, September 29 - October 2, 2006
