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Polymorphisms of the inflammatory system and risk of ischemic cerebrovascular events

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Published/Copyright: July 31, 2006
Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Clinical Chemistry and Laboratory Medicine (CCLM) Volume 44 Issue 8

Abstract

Background: Chronic and acute infections are associated with an increased risk of stroke. The inflammatory response can be influenced by functional polymorphisms in components of the immune system. We hypothesized that these polymorphisms may also modulate the risk of ischemic cerebrovascular events.

Methods: We determined the frequency of polymorphisms in tumor necrosis factor-α[(TNF-α) G(–376)A, G(–244)A, G(–238)A, G(–308)A], Toll-like receptor 4 [(TLR4) Gly299Asp and Thr399Ile], interleukin-1-receptor antagonist [(IL-1-RA) intron 2 variable-number tandem repeat], monocyte differentiation antigen CD14 receptor C(–260)T, and interleukin-6 [(IL-6) G(–174)C] genes in 404 patients with acute stroke or transient ischemic attack before the age of 60years and in 415 healthy individuals. We also tested for interactions between genotypes, recent febrile episodes and stroke risk.

Results: None of the polymorphisms was associated with an increased risk of stroke after adjustment for age and gender. Following multivariate adjustment, carriers of the TNF-α (–308)A allele, the IL-1-RA 2* allele or the IL-6 (–174)C allele appeared to have an increased risk of stroke in association with a febrile episode prior to strokes.

Conclusion: In our study none of the investigated polymorphisms of the inflammatory system was associated with the risk of acute cerebrovascular events before the age of 60years. However, post-hoc analyses indicate that some polymorphisms seem to contribute to the risk of stroke in combination with fever.

Clin Chem Lab Med 2006;44:918–23.

Keywords: infection; inflammation; interleukins; polymorphism; stroke; tumor necrosis factor
Corresponding author: Prof. Wolfgang Lalouschek, MD, University Clinic of Neurology, Clinical Department of Clinical Neurology, Waehringer Guertel 18-20, 1097 Vienna, Austria Phone: +43-1-40400-3117, Fax: +43-1-40400-3141

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Received: 2006-1-26
Accepted: 2006-4-21
Published Online: 2006-7-31
Published in Print: 2006-8-1

©2006 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2006.165
Keywords for this article
infection; inflammation; interleukins; polymorphism; stroke; tumor necrosis factor

Articles in the same Issue

  1. Laboratory medicine in the 2000s: programmed death or rebirth?
  2. Polymorphisms of the inflammatory system and risk of ischemic cerebrovascular events
  3. Haptoglobin polymorphism in patients with preeclampsia
  4. Fifteen polymorphisms in endothelin-1, endothelin-2 and endothelin-receptor-A genotyped by four duplex assays and seven simple assays on a LightCycler using hybridization probes
  5. Optimization of an enzymatic method for the determination of lysosomal N-acetyl-β-D-hexosaminidase and β-glucuronidase in synovial fluid
  6. An improved laboratory protocol to assess subarachnoid haemorrhage in patients with negative cranial CT scan
  7. Association of aminothiols with the clinical outcome in hemodialysis patients: comparison of chromatography and immunoassay for homocysteine determination
  8. Poor prognosis indicated by nucleated red blood cells in peripheral blood is not associated with organ failure of the liver or kidney
  9. Detection of citrate overdose in critically ill patients on citrate-anticoagulated venovenous haemofiltration: use of ionised and total/ionised calcium
  10. Unchanged androgen-binding properties of sex hormone-binding globulin in male patients with liver cirrhosis
  11. Relationship between serum uric acid, creatinine, albumin and gestational diabetes mellitus
  12. Aminothiols in human brain tumors
  13. Measurement of carnitine in hemodialysis patients – adaptation of an enzymatic photometric method for an automatic analyzer
  14. A robust liquid chromatography tandem mass spectrometry method for total plasma homocysteine determination in clinical practice
  15. Establishment of reference distributions and decision values for thyroid antibodies against thyroid peroxidase (TPOAb), thyroglobulin (TgAb) and the thyrotropin receptor (TRAb)
  16. Effects of a long-distance run on cardiac markers in healthy athletes
  17. α-Tocopherol supplementation reduces the elevated 8-hydroxy-2-deoxyguanosine blood levels induced by training in basketball players
  18. Influence of the needle bore size used for collecting venous blood samples on routine clinical chemistry testing
  19. The ratio of apoB/apoAI, apoB and lipoprotein(a) are the best predictors of stable coronary artery disease
  20. Evaluation of the analytical performance of the advanced method for cardiac troponin I for the AxSYM platform: comparison with the old method and the Access system
  21. Preliminary performance evaluation of blood gas analyzers
  22. A cost-effectiveness evaluation of reticulocyte measurement in new outpatients with or without hematologic disorders
  23. Guidelines for setting up an External Quality Assessment Scheme for blood smear interpretation. Part II: survey preparation, statistical evaluation and reporting
  24. Free light chain testing in follow-up of multiple myeloma
  25. Blood reactive oxygen metabolites (ROMs) and total antioxidant status (TAS) in patients with laryngeal squamous cell carcinoma after surgical treatment
  26. SIBioC 2006 38th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology, Turin, Italy, September 19–22, 2006
  27. Third Santorini Biologie Prospective Conference 2006: From Human Genetic Variations to Prediction of Risks and Responses to Drugs and the Environment, Santorini Island, Greece, September 29 - October 2, 2006
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