Association of angiotensin II type 1 receptor gene polymorphism with carotid atherosclerosis
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Shiming Zhu
Abstract
Background: Polymorphisms of the angiotensin II type 1 receptor (AGTR1) gene are associated with essential hypertension and cardiovascular disease, but the correlation between AGTR1 A1166C polymorphism and carotid intima-media thickness (IMT) remains unclear. We sought to demonstrate correlation between AGTR1 gene polymorphism and carotid atherosclerosis in a Chinese population.
Method: A total of 150 patients diagnosed with essential hypertension were included in this study. The AGTR1 A1166C polymorphism was detected by restriction analysis of the polymerase chain reaction product with Ddel digestion. Carotid IMT was measured by B-mode ultrasonography.
Results: The AC genotype frequency and the C1166 allele frequency of the AGTR1 gene in essential hypertensive patients were significantly higher than in controls (22.00% vs. 6.00% for AC, p<0.01; 18.67% vs. 8.00% for the C allele, p<0.05). Hypertensive subjects with the AC genotype had increased carotid artery IMT and IMT/D (common carotid artery diameter) ratio compared with the AA genotype (IMT 1.14±0.39 vs. 0.88±0.16, p<0.05; IMT/D 14.08±2.88 vs. 10.51±1.94, p<0.01).
Conclusion: These results suggest that the AGTR1 A1166C polymorphism is associated with essential hypertension and carotid atherosclerosis in a Chinese population.
References
1. Fatini C, Abbate R, Pepe G, Battaglini B, Gensini F, Ruggiano G, et al. Searching for a better assessment of the individual coronary risk profile. The role of angiotensin-converting enzyme, angiotensin II type 1 receptor and angiotensinogen gene polymorphisms. Eur Heart J 2000; 21:633–8.10.1053/euhj.1999.1738Search in Google Scholar
2. Bonnardeaux A, Davies E, Jeunemaitre X, Fery I, Charru A, Clauser E, et al. Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension 1994; 24:63–9.10.1161/01.HYP.24.1.63Search in Google Scholar
3. Wang WY, Zee RY, Morris BJ. Association of angiotensin II type 1 receptor gene polymorphism with essential hypertension. Clin Genet 1997; 51:31–4.10.1111/j.1399-0004.1997.tb02410.xSearch in Google Scholar
4. Benetos A, Topouchian J, Ricard S, Gautier S, Bonnardeaux A, Asmar R, et al. Influence of angiotensin II type 1 receptor polymorphism on aortic stiffness in never-treated hypertensive patients. Hypertension 1995; 26:44–7.10.1161/01.HYP.26.1.44Search in Google Scholar
5. Tiret L, Bonnardeaux A, Poirier O, Ricard S, Marques-Vidal P, Evans A, et al. Synergistic effects of angiotensin-converting enzyme and angiotensin-II type 1 receptor gene polymorphisms on risk of myocardial infarction. Lancet 1994; 344:910–3.10.1016/S0140-6736(94)92268-3Search in Google Scholar
6. Canavy I, Henry M, Morange PE, Tiret L, Poirier O, Ebagosti A, et al. Genetic polymorphisms and coronary artery disease in the south of France. Thromb Haemost 2000; 83:212–6.10.1055/s-0037-1613788Search in Google Scholar
7. Chapman CM, Palmer LJ, McQuillan BM, Hung J, Burley J, Hunt C, et al. Polymorphisms in the angiotensinogen gene are associated with carotid intima-medial thickening in females from a community-based population. Atherosclerosis 2001; 159:209–17.10.1016/S0021-9150(01)00499-3Search in Google Scholar
8. Castellano M, Muiesan ML, Beschi M, Rizzoni D, Cinelli A, Salvetti M, et al. Angiotensin II type 1 receptor A/C1166 polymorphism. Relationships with blood pressure and cardiovascular structure. Hypertension 1996; 28:1076–80.10.1161/01.HYP.28.6.1076Search in Google Scholar
9. Girerd X, Hanon O, Mourad JJ, Boutouyrie P, Laurent S, Jeunemaitre X. Lack of association between renin-angiotensin system, gene polymorphisms, and wall thickness of the radial and carotid arteries. Hypertension 1998; 32:579–83.10.1161/01.HYP.32.3.579Search in Google Scholar
10. Tabara Y, Kohara K, Nakura J, Miki T. Risk factor-gene interaction in carotid atherosclerosis: effect of gene polymorphisms of renin-angiotensin system. J Hum Genet 2001; 46:278–84.10.1007/s100380170079Search in Google Scholar PubMed
11. Pontremoli R, Ravera M, Viazzi F, Nicolella C, Berruti V, Leoncini G, et al. Genetic polymorphism of the renin-angiotensin system and organ damage in essential hypertension. Kidney Int 2000; 57:561–9.10.1046/j.1523-1755.2000.00876.xSearch in Google Scholar PubMed
12. Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE. Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 1997; 96:1432–7.10.1161/01.CIR.96.5.1432Search in Google Scholar
13. Manolio TA, Boerwinkle E, O'Donnell CJ, Wilson AF. Genetics of ultrasonographic carotid atherosclerosis. Arterioscler Thromb Vasc Biol 2004; 24:1567–77.10.1161/01.ATV.0000138789.11433.c1Search in Google Scholar PubMed
14. Jerrard-Dunne P, Markus HS, Steckel DA, Buehler A, von Kegler S, Sitzer M. Early carotid atherosclerosis and family history of vascular disease: specific effects on arterial sites have implications for genetic studies. Arterioscler Thromb Vasc Biol 2003; 23:302–6.10.1161/01.ATV.0000051383.75507.60Search in Google Scholar
©2006 by Walter de Gruyter Berlin New York
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- Recent advances in physiological calcium homeostasis
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- Association of angiotensin II type 1 receptor gene polymorphism with carotid atherosclerosis
- Comparison of the TaqMan and LightCycler systems in pharmacogenetic testing: evaluation of CYP2C9*2/*3 polymorphisms
- Urinary cystatin C as a specific marker of tubular dysfunction
- Time-resolved fluorimetric immunoassay of calprotectin: technical and clinical aspects in diagnosis of inflammatory bowel diseases
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- Markers of oxidative stress in children with Down syndrome
- Influence of hemolysis on routine clinical chemistry testing
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- Comparison of the lipid profile and lipoprotein(a) between sedentary and highly trained subjects
- Clinical outcome estimates based on treatment target limits of laboratory tests: proposal for a plot visualizing effects and differences of medical target setting exemplified by glycemic control in diabetes
- Metrological traceability of values for catalytic concentration of enzymes assigned to a calibration material
- Evaluation of a new Sebia kit for analysis of hemoglobin fractions and variants on the Capillarys® system
- Recommendation for measuring and reporting chloride by ISEs in undiluted serum, plasma or blood: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC): IFCC Scientific Division, Committee on Point of Care Testing and Working Group on Selective Electrodes
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