Elevated plasma cysteinylglycine levels caused by cilastatin-associated antibiotic treatment
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Stéphanie Badiou
Abstract
Imipenem (thienamycin formamidine), a broad-spectrum β-lactam antibiotic, is always used in combination with cilastatin in order to avoid the premature breakdown of imipenem by renal tubular dipeptidase. As this dipeptidase also hydrolyzes the glutathione metabolite cysteinylglycine, the therapeutic asso-ciation of imipenem and cilastatin might cause an accumulation of the aminothiol cysteinylglycine. We demonstrate here that when patients are treated with imipenem-cilastatin, their plasma levels of cysteinylglycine are significantly and specifically increased, while cysteine levels are decreased and homocysteine levels are unaffected. We conclude that antibiotic treatment using imipenem-cilastatin induces important metabolic changes that should not remain unrecognized.
References
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©2005 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock
- Conjugated linoleic acid suppresses the secretion of atherogenic lipoproteins from human HepG2 liver cells
- Determination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship
- Assessment of iodine intake in mildly iodine-deficient pregnant women by a new automated kinetic urinary iodine determination method
- Butyrylcholinesterase activity and metabolic syndrome in obese patients
- The non-thyroidal illness syndrome after coronary artery bypass grafting: a 6-month follow-up study
- Advanced oxidation protein products (AOPP) for monitoring oxidative stress in critically ill patients: a simple, fast and inexpensive automated technique
- Quality control in urinary stone analysis: results of 44 ring trials (1980–2001)
- External Quality Assessment in The Netherlands: time to introduce commutable survey specimens. Lessons from the Dutch “Calibration 2000” project
- Evaluation of a high-sensitivity turbidimetric immunoassay for serum C-reactive protein: application to the study of longitudinal changes throughout normal pregnancy
- A quantitative appraisal of interference by icodextrin metabolites in point-of-care glucose analyses
- Preanalytical variability in laboratory testing: influence of the blood drawing technique
- Soluble transferrin receptor and transferrin receptor-ferritin index in iron deficiency anemia and anemia in rheumatoid arthritis
- Elevated plasma cysteinylglycine levels caused by cilastatin-associated antibiotic treatment
- The number of consultant clinical chemists in the 15-nation European Union
- Biological variation of vascular endothelial growth factor
- Terminology, categories and representation of examinations in laboratory medicine
- Reply to W.G. Wood. Questionable results – who directs the EQAS organisers? Clin Chem Lab Med 2004;42:1073
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- 4th Conference on Hyperhomocysteinemia: Saarbrücken, Germany, April, 14–16, 2005, Saarland University