Effect of prolonged physical exercise on urinary proANP1-30 and proANP31-67
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Enrico Cappellin
Abstract
Dynamic exercise strongly affects atrial natriuretic peptides (ANP), in particular the mature bioactive αANP and the proANP fragments, namely proANP1–98, proANP1–30 and proANP31–67. The proANPs influence kidney functions and their plasma levels increase after physical exercise. We measured urinary proANP1–30 and proANP31–67 levels before and at the end of physical exercise in 28 well-trained male cyclists. For the first time, the proANP1–30 and proANP31–67 urinary levels in athletes before and at the end of a prolonged agonistic bicycle race were measured. Urinary creatinine and total proteins were also measured. The urinary proANP31–67, creatinine and total protein levels were significantly higher at the end of exercise than before. In contrast, proANP1–30/protein and proANP31–67/protein ratios decreased after exercise. Even proANP1–30/creatinine and proANP31–67/creatinine ratios were lower after exercise. A significant correlation between proANP1–30 and proANP31–67 urinary levels at the end of exercise was found. The proANP31–67/creatinine ratio before and after exercise also showed a significant correlation. The variation of urinary proANP fragments confirmed their possible role in physical exercise. In particular, it could be interpreted as a response of the body or kidney to renal impairment occurring during exercise.
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© Walter de Gruyter
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- Genetic and immunological analyses of patients with increased serum butyrylcholinesterase activity and its C5 variant form
- Polymorphisms in the P-selectin (CD62P) and P-selectin glycoprotein ligand-1 (PSGL-1) genes and coronary heart disease
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