Low S-adenosylmethionine concentrations found in patients with severe inflammatory bowel disease
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Anne Schmedes
Abstract
Background: S-adenosylmethionine is a methyl donor in many cellular reactions including detoxification of constantly produced hydrogen sulphide in the colon. A reduced capacity to detoxify hydrogen sulphide may be implicated in the pathogenesis of inflammatory bowel disease. S-adenosylmethionine could be low if this assumption is correct. We compared S-adenosylmethionine concentrations in whole blood in patients with severe and moderate inflammatory bowel disease with healthy reference persons. Methods: S-adenosylmethionine concentrations in whole blood were measured using high-pressure liquid chromatography. Patients with Crohn's disease (n=21), ulcerative colitis (n=7) and healthy age-matched reference persons (or controls) (n=17) were studied. Results: S-adenosylmethionine concentrations were significantly decreased in patients with severe inflammatory bowel disease (mean 1.10 mg/l) as compared to patients with moderate Crohn's disease and ulcerative colitis (mean 1.83 mg/l) and reference persons (mean 1.84 mg/l). Statistically significant inverse correlations were found between S-adenosylmethionine concentration and activity index (p<0.01 and R2=0.86) as well as Crohn's disease activity index (p<0.01 and R2=0.50) scores. Conclusions: Low concentrations of S-adenosylmethionine were found in patients with severe inflammatory bowel disease. Future studies will show whether S-adenosylmethionine is a marker for disease activity and a possible tool for investigation of sulphur toxicity as a causative mechanism in inflammatory bowel disease.
Copyright (c) 2004 by Walter de Gruyter GmbH & Co. KG
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Artikel in diesem Heft
- Publishers note
- Towards quality specifications in extra-analytical phases of laboratory activity
- Quality indicators and specifications for the extra-analytical phases in clinical laboratory management
- Pitfalls and drawbacks in screening of congenital disorders of glycosylation
- Activity of eosinophils and immunoglobulin E concentration in the peritoneal fluid of women with endometriosis
- Rapid generation of detailed loss of heterozygosity profiles for routine diagnosis of gliomas
- Presence of secretory group IIa and V phospholipase A2 and cytosolic group IVα phospholipase A2 in chondrocytes from patients with rheumatoid arthritis
- Neurokinin B levels in maternal circulation during early pregnancy
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- Cardiac natriuretic hormones, neuro-hormones, thyroid hormones and cytokines in normal subjects and patients with heart failure
- Clinical utility of serum holotranscobalamin as a marker of cobalamin status in elderly patients with neuropsychiatric symptoms
- Comparison of serum creatinine, uric acid, albumin and glucose in male professional endurance athletes compared with healthy controls
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- The influence of freezer storage of urine samples on the BONN-Risk-Index for calcium oxalate crystallization
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