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Age dependence of serum β-N-acetylhexosaminidase (NAG) activity

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Published/Copyright: June 1, 2005
Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Clinical Chemistry and Laboratory Medicine (CCLM) Volume 42 Issue 3

Abstract

Serum N-acetyl-β-D-glucosaminidase (NAG; EC 3.2.1.30) is a hexosaminidase and may be a predictor of vascular injury, e.g., in infant respiratory distress syndrome, pneumonia, broncho-pulmonary dysplasia and necrotizing enterocolitis. To estimate the new diagnostic prospects we have modified our urinary NAG assay. In this sensitive colorimetric micro-assay, VRA-GlcNAc was used as a substrate. In the present study the age dependence of serum NAG activity was investigated in newborn babies, infants (1–24 months), children (2–18 years) and adults (19–80 years). Serum NAG activity was found to be age-dependent; it is higher in early childhood (11–59 U/l) but decreases to a constant value at the age of 1–2 years. After the age of 2 years it is similar to adults' NAG (10–30 U/l). In pediatrics age-matched reference ranges must be taken into consideration.

Published Online: 2005-6-1
Published in Print: 2004-3-9

Copyright © 2004 by Walter de Gruyter GmbH & Co. KG

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https://doi.org/10.1515/CCLM.2004.055

Articles in the same Issue

  1. Phage-displayed recombinant single-chain antibody fragments with high affinity for cholesteryl ester transfer protein (CETP): cDNA cloning, characterization and CETP quantification
  2. Stem cell factor and macrophage-colony stimulating factor in patients with pancreatic cancer
  3. Modulation of plasma fibrinogen levels in acute-phase response after hepatectomy
  4. Anti-nucleosome, anti-chromatin, anti-dsDNA and anti-histone antibody reactivity in systemic lupus erythematosus
  5. Expression of activation molecules in neutrophils, monocytes and lymphocytes from patients with unstable angina treated with stent implantation
  6. Acid ribonuclease and alkaline ribonuclease isoenzymes in plasma of patients with decreased glomerular filtration rate
  7. Is calcium oxalate nucleation in postprandial urine of males with idiopathic recurrent calcium urolithiasis related to calcium phosphate nucleation and the intensity of stone formation? Studies allowing insight into a possible role of urinary free citrate and protein
  8. Significance of consecutive international normalized ratio (INR) outcomes using statistical control rules in long-term anticoagulated patients. Optimization of laboratory monitoring and interpretation of borderline measurements
  9. Clinical trials and p-values, beware of the extremes
  10. Age dependence of serum β-N-acetylhexosaminidase (NAG) activity
  11. Elevated plasma total homocysteine in centenarians
  12. New methodology of influential point detection in regression model building for the prediction of metabolic clearance rate of glucose
  13. Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors
  14. The glutathione S-transferase polymorphisms in a control population and in Alzheimer's disease patients
  15. Near-patient testing for infection using urinalysis and immuno-chromatography strips
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  18. Re.: Correction to the IFCC primary reference method for the measurement of catalytic activity concentration of enzymes at 37C- part 2: reference procedure for the measurement of creatine kinase. Clin Chem Lab Med 2002;40:635-42
  19. Meetings and Awards
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