Steroids, Sex Hormone-Binding Globulin, Homocysteine, Selected Hormones and Markers of Lipid and Carbohydrate Metabolism in Patients with Severe Hypothyroidism and Their Changes Following Thyroid Hormone Supplementation
-
Marie Bičíková
Abstract
Laboratory markers of thyroid function, selected steroid hormones, sex hormone-binding globulin (SHBG), homocysteine, prolactin, major markers of lipid- and glucose metabolism and of insular-growth hormone axes were investigated in fasting sera from 16 female patients with severe hypothyroidism after thyroidectomy because of thyroid cancer. The results obtained in severe hypothyroidism within 5–6 weeks after withdrawal of thyroid substitution therapy before control scintigraphy were compared with those obtained after correction of thyroid function. Elevated levels of homocysteine and prolactin in hypothyroidism significantly decreased after correction, while SHBG concentration increased. Correction of thyroid function led to significant changes of growth hormone and immunoglobulin F1 (decrease and increase, respectively), while insulin and proinsulin increased only insignificantly. Elevated levels of total cholesterol and triglycerides in hypothyroidism were normalized, along with a significant increase in high density lipoprotein (HDL)-cholesterol. As revealed by correlation and factor analyses, different relationships characterizing both states were found in hypothyroidism and after correction of thyroid function. A strong inverse relationship between homocysteine and free thyroid hormones confirms the effect of thyroid hormones on homocysteine metabolism. No such inverse relation was found in euthyroid state, however. Similarly, in hypothyroidism only, dehydroepiandrosterone sulfate correlated positively with immunoglobulin F1 and homocysteine and negatively with thyroid hormones and SHBG.
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- 3rd Conference on Hyperhomocysteinemia Saarbrücken, Germany, 11–12 April 2003, Saarland University
- Platelet Receptors and Their Role in Diseases
- Real-Time RT-PCR for the Measurement of Prostate-Specific Antigen mRNA Expression in Benign Hyperplasia and Adenocarcinoma of Prostate
- Detection of a Novel Exon 4 Low-Density Lipoprotein Receptor Gene Deletion in a Swiss Family with Severe Familial Hypercholesterolemia
- Absence of Known Familial Hemiplegic Migraine (FHM) Mutations in the CACNA1A Gene in Patients with common Migraine: Implications for Genetic Testing
- Association between 5,10-Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Conotruncal Heart Defects
- Rapid and Reliable Genotyping of the C181T Polymorphism in the Bradykinin B2 Receptor Gene
- Steroids, Sex Hormone-Binding Globulin, Homocysteine, Selected Hormones and Markers of Lipid and Carbohydrate Metabolism in Patients with Severe Hypothyroidism and Their Changes Following Thyroid Hormone Supplementation
- Anaerobic Bacteremia: The Yield of Positive Anaerobic Blood Cultures: Patient Characteristics and Potential Risk Factors
- Genotyping of Alcohol Dehydrogenase Type 2 and 3 Using a Two-Buffer Polyacrylamide Gel Electrophoresis System
- Effect of Partial Proteolysis on the Activation Energy of β-N-Acetylhexosaminidase Precursor and Mature Forms
- Angiogenin and Gestational Trophoblastic Tumors, a Promising Prognostic Marker
- Carbohydrate 19-9 Antigen Is Not a Marker of Liver Disease in Patients with Cystic Fibrosis
- Assay Using Succinyldithiocholine as Substrate: The Method of Choice for the Measurement of Cholinesterase Catalytic Activity in Serum to Diagnose Succinyldicholine Sensitivity
- National External Quality Assessment Scheme for Lymphocyte Immunophenotyping in Belgium
- Quality Assurance for Cerebrospinal Fluid Protein Analysis: International Consensus by an Internet-Based Group Discussion
- Guidelines for the Analysis of Bence Jones Protein
- Discordance Rate, a New Concept for Combining Diagnostic Decisions with Analytical Performance Characteristics. 1. Application in Method or Sample System Comparisons and in Defining Decision Limits
- Urinary Homogentisic Acid in Alkaptonuric and Healthy Children
- The Influence of Hemolysis, Turbidity and Icterus on the Measurements of CK-MB, Troponin I and Myoglobin
- Evaluation of Cobas Integra® 800 under Simulated Routine Conditions in Six Laboratories
- Guidelines for the Laboratory Investigation of Inherited Thrombophilias. Recommendations for the First Level Clinical Laboratories
- Detection of PvuII Polymorphism within Intron 1 of ESR1 Gene by Real-Time PCR
- Meetings and Awards
Articles in the same Issue
- 3rd Conference on Hyperhomocysteinemia Saarbrücken, Germany, 11–12 April 2003, Saarland University
- Platelet Receptors and Their Role in Diseases
- Real-Time RT-PCR for the Measurement of Prostate-Specific Antigen mRNA Expression in Benign Hyperplasia and Adenocarcinoma of Prostate
- Detection of a Novel Exon 4 Low-Density Lipoprotein Receptor Gene Deletion in a Swiss Family with Severe Familial Hypercholesterolemia
- Absence of Known Familial Hemiplegic Migraine (FHM) Mutations in the CACNA1A Gene in Patients with common Migraine: Implications for Genetic Testing
- Association between 5,10-Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Conotruncal Heart Defects
- Rapid and Reliable Genotyping of the C181T Polymorphism in the Bradykinin B2 Receptor Gene
- Steroids, Sex Hormone-Binding Globulin, Homocysteine, Selected Hormones and Markers of Lipid and Carbohydrate Metabolism in Patients with Severe Hypothyroidism and Their Changes Following Thyroid Hormone Supplementation
- Anaerobic Bacteremia: The Yield of Positive Anaerobic Blood Cultures: Patient Characteristics and Potential Risk Factors
- Genotyping of Alcohol Dehydrogenase Type 2 and 3 Using a Two-Buffer Polyacrylamide Gel Electrophoresis System
- Effect of Partial Proteolysis on the Activation Energy of β-N-Acetylhexosaminidase Precursor and Mature Forms
- Angiogenin and Gestational Trophoblastic Tumors, a Promising Prognostic Marker
- Carbohydrate 19-9 Antigen Is Not a Marker of Liver Disease in Patients with Cystic Fibrosis
- Assay Using Succinyldithiocholine as Substrate: The Method of Choice for the Measurement of Cholinesterase Catalytic Activity in Serum to Diagnose Succinyldicholine Sensitivity
- National External Quality Assessment Scheme for Lymphocyte Immunophenotyping in Belgium
- Quality Assurance for Cerebrospinal Fluid Protein Analysis: International Consensus by an Internet-Based Group Discussion
- Guidelines for the Analysis of Bence Jones Protein
- Discordance Rate, a New Concept for Combining Diagnostic Decisions with Analytical Performance Characteristics. 1. Application in Method or Sample System Comparisons and in Defining Decision Limits
- Urinary Homogentisic Acid in Alkaptonuric and Healthy Children
- The Influence of Hemolysis, Turbidity and Icterus on the Measurements of CK-MB, Troponin I and Myoglobin
- Evaluation of Cobas Integra® 800 under Simulated Routine Conditions in Six Laboratories
- Guidelines for the Laboratory Investigation of Inherited Thrombophilias. Recommendations for the First Level Clinical Laboratories
- Detection of PvuII Polymorphism within Intron 1 of ESR1 Gene by Real-Time PCR
- Meetings and Awards
