Article
Licensed
Unlicensed
Requires Authentication
Rapid Determination of Brain Natriuretic Peptide in Patients with Acute Myocardial Infarction
-
Mauro Panteghini
Published/Copyright:
June 1, 2005
Abstract
We evaluated a rapid brain natriuretic peptide (BNP) assay (Triage® BNP, Biosite Diagnostics) as indicator of infarct size, left ventricular (LV) dysfunction, and long-term survival in patients with acute myocardial infarction (AMI) during the coronary care unit stay. We studied 64 AMI patients in whom infarct size was estimated by creatine kinase isoenzyme MB (CK-MB) peak concentrations and single-photon emission computed tomography (SPECT) myocardial perfusion using technetium-99m sestamibi, and LV function by gated SPECT imaging. Measurements of BNP and SPECT were performed approximately 3 days after admission. SPECT was also repeated 3 months later. We found a significant correlation between BNP and both the peak CK-MB concentrations (r = 0.40, p = 0.001) and the perfusion defect size at SPECT (r = 0.38, p = 0.002). BNP was weakly related to LV ejection fraction (LVEF) assessed both early and 3 months after AMI (r = −0.29, p = 0.02; and r = −0.27, p = 0.04, respectively). The sensitivity and specificity of BNP for predicting survival of patients over 1 year of follow-up was 100% and 43%, respectively, with a negative predictive value of 100%. The positive predictive power of BNP was very modest (12%). Considering our results, the measurement of BNP did not look nearly as promising when tested in the setting of our cardiological intensive care.
:
Published Online: 2005-06-01
Published in Print: 2003-02-21
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Erythrocyte Sedimentation Rate: Innovative Techniques for an Obsolete Test?
- Liquid Chromatography-Tandem Mass Spectrometry – Application in the Clinical Laboratory
- New Sensitive Method for the Measurement of Lysozyme and Lactoferrin for the Assessment of Innate Mucosal Immunity. Part I: Time-Resolved Immunofluorometric Assay in Serum and Mucosal Secretions
- New Sensitive Method for the Measurement of Lysozyme and Lactoferrin to Explore Mucosal Innate Immunity. Part II: Time-Resolved Immunofluorometric Assay Used in HIV Patients with Oral Candidiasis
- Detection of Multiple Cytokines by Protein Arrays from Cell Lysate and Tissue Lysate
- Free Serum Cortisol during the Postoperative Acute Phase Response Determined by Equilibrium Dialysis Liquid Chromatography-Tandem Mass Spectrometry
- Analysis of the Dynamics of Cryoaggregation by Light-Scattering Spectrometry
- Biliary Bacteria in Living Related Liver Transplant Recipients: Microbiology and Rapid Detection System Using Flow Cytometry
- Rapid Determination of Brain Natriuretic Peptide in Patients with Acute Myocardial Infarction
- Preparation and Characterization of Reference Materials for Human Pancreatic Lipase: BCR 693 (from Human Pancreatic Juice) and BCR 694 (Recombinant)
- Commutability of the CRM 470 C-Reactive Protein Value in the Dade Behring N High Sensitivity CRP Assay
- Pilot External Quality Assessment Survey for Post-Market Vigilance of In Vitro Diagnostic Medical Devices and Investigation of Trueness of Participants' Results
- Fasting and Post-Glucose Load – Reference Limits for Peripheral Venous Plasma Glucose Concentration in Pregnant Women
- Glutathione Peroxidase Activity and Serum Selenium Concentration in Intrinsic Asthmatic Patients
- Increased Serum Soluble Transferrin Receptor Concentration Detects Subclinical Iron Deficiency in Healthy Adolescent Girls
- Serum Total Antioxidant Status, Erythrocyte Superoxide Dismutase and Whole-Blood Glutathione Peroxidase Activities in the Stanislas Cohort: Influencing Factors and Reference Intervals
- Plasma Thiols and Androgen Levels in Polycystic Ovary Syndrome
- Pretreatment of Serum Containing Hemoglobin Vesicles (Oxygen Carriers) to Prevent Their Interference in Laboratory Tests
- Length of Sedimentation Reaction in Blood: a Comparison of the Test 1 ESR System with the ICSH Reference Method and the Sedisystem 15
- The European Register for Specialists in Clinical Chemistry and Laboratory Medicine: Guide to the Register Version 2-2003 and Procedure for Re-registration
- Journées Internationales de Biologie – JIB 2002: A Booming European Show!
- Meetings and Awards
Articles in the same Issue
- Erythrocyte Sedimentation Rate: Innovative Techniques for an Obsolete Test?
- Liquid Chromatography-Tandem Mass Spectrometry – Application in the Clinical Laboratory
- New Sensitive Method for the Measurement of Lysozyme and Lactoferrin for the Assessment of Innate Mucosal Immunity. Part I: Time-Resolved Immunofluorometric Assay in Serum and Mucosal Secretions
- New Sensitive Method for the Measurement of Lysozyme and Lactoferrin to Explore Mucosal Innate Immunity. Part II: Time-Resolved Immunofluorometric Assay Used in HIV Patients with Oral Candidiasis
- Detection of Multiple Cytokines by Protein Arrays from Cell Lysate and Tissue Lysate
- Free Serum Cortisol during the Postoperative Acute Phase Response Determined by Equilibrium Dialysis Liquid Chromatography-Tandem Mass Spectrometry
- Analysis of the Dynamics of Cryoaggregation by Light-Scattering Spectrometry
- Biliary Bacteria in Living Related Liver Transplant Recipients: Microbiology and Rapid Detection System Using Flow Cytometry
- Rapid Determination of Brain Natriuretic Peptide in Patients with Acute Myocardial Infarction
- Preparation and Characterization of Reference Materials for Human Pancreatic Lipase: BCR 693 (from Human Pancreatic Juice) and BCR 694 (Recombinant)
- Commutability of the CRM 470 C-Reactive Protein Value in the Dade Behring N High Sensitivity CRP Assay
- Pilot External Quality Assessment Survey for Post-Market Vigilance of In Vitro Diagnostic Medical Devices and Investigation of Trueness of Participants' Results
- Fasting and Post-Glucose Load – Reference Limits for Peripheral Venous Plasma Glucose Concentration in Pregnant Women
- Glutathione Peroxidase Activity and Serum Selenium Concentration in Intrinsic Asthmatic Patients
- Increased Serum Soluble Transferrin Receptor Concentration Detects Subclinical Iron Deficiency in Healthy Adolescent Girls
- Serum Total Antioxidant Status, Erythrocyte Superoxide Dismutase and Whole-Blood Glutathione Peroxidase Activities in the Stanislas Cohort: Influencing Factors and Reference Intervals
- Plasma Thiols and Androgen Levels in Polycystic Ovary Syndrome
- Pretreatment of Serum Containing Hemoglobin Vesicles (Oxygen Carriers) to Prevent Their Interference in Laboratory Tests
- Length of Sedimentation Reaction in Blood: a Comparison of the Test 1 ESR System with the ICSH Reference Method and the Sedisystem 15
- The European Register for Specialists in Clinical Chemistry and Laboratory Medicine: Guide to the Register Version 2-2003 and Procedure for Re-registration
- Journées Internationales de Biologie – JIB 2002: A Booming European Show!
- Meetings and Awards
