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The Paraoxonase-1 Codon192 Polymorphism Is Associated with Fasting Total Cholesterol and LDL-Cholesterol Concentrations only in Postmenopausal Women.The REGICOR Study

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Published/Copyright: June 1, 2005
Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 40 Issue 7

Abstract

Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL)-linked enzyme which appears to protect low-density lipoproteins (LDL) from oxidation. PON1 activity is associated with variation at the PON1 gene locus, specifically the common amino acid polymorphism at codon 192, for which the Q192 allele specifies low activity and the R192 allele specifies high activity. We investigated the association between the PON1 codon 192 polymorphism and fasting concentrations of glucose, lipids, lipoproteins and PON1 activity in 1380 subjects (724 men and 656 women). Several anthropometric and environmental factors were assessed in the present study. The PON1 Q192 allele frequency was 0.70 and 0.68 in men and women, respectively. In women, but not in men, significant associations were found between the PON1 codon 192 genotype and both total and LDL-cholesterol (p=0.004 and p=0.008, respectively), and subgroup analysis indicated that this relationship was predominant in postmenopausal women. Specifically, the Q192 allele was associated with increased total and LDL-cholesterol concentrations. Furthermore, these lipoprotein variables were higher among postmenopausal women with Q192/Q192 and Q192/R192 genotypes than in premenopausal women with the same genotypes (p<0.001). The findings suggest a gender-specific lipoprotein-genotype association with PON1 codon 192 genotypes in this study sample.

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Published Online: 2005-06-01
Published in Print: 2002-07-24

Copyright © 2002 by Walter de Gruyter GmbH & Co. KG

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https://doi.org/10.1515/CCLM.2002.116

Articles in the same Issue

  1. Mechanisms of Hyperammonemia
  2. Neopterin – an Early Marker of Surgical Stress and Hypoxic Reperfusion Damage during Liver Surgery
  3. Isolation of Fetal Nucleated Red Blood Cells from Maternal Blood in Normal and Aneuploid Pregnancies
  4. Evaluation of an Automated Spectrophotometric Assay for Reactive Oxygen Metabolites in Serum
  5. The Paraoxonase-1 Codon192 Polymorphism Is Associated with Fasting Total Cholesterol and LDL-Cholesterol Concentrations only in Postmenopausal Women.The REGICOR Study
  6. Serum Oxidant/Antioxidant Status in Patients with Systemic Lupus Erythematosus
  7. Frequencies of C28Y and H63D Mutations and Transferrin Saturation Indices in the Korean Population
  8. Validation of the Phenylalanine/Tyrosine Ratio Determined by Tandem Mass Spectrometry: Sensitive Newborn Screening for Phenylketonuria
  9. Multicenter Study of the LCx® HIV RNA Quantitative Assay – a New Competitive Reverse Transcriptase-PCR which Targets pol Genomic Region of HIV-1 for the Measurement of Type B, Non-Type B and Group O HIV-1 RNA
  10. The Interference of Insulin Antibodies in Insulin Immunometric Assays
  11. A Comparison of Different Sample Matrices for Evaluating Functional Sensitivity, Imprecision and Dilution Linearity of the Abbott ARCHITECT® i2000® TSH Assay
  12. Determination of the Length of Sedimentation Reaction (Erythrocyte Sedimentation Rate) in Non-Anticoagulated Blood with the Microtest 1
  13. IFCC Primary Reference Procedures for the Measurement of Catalytic Activity Concentrations of Enzymes at 37°C. Part 4. Reference Procedure for the Measurement of Catalytic Concentration of Alanine Aminotransferase
  14. IFCC Primary Reference Procedures for the Measurement of Catalytic Activity Concentrations of Enzymes at 37°C. Part 5. Reference Procedure for the Measurement of Catalytic Concentration of Aspartate Aminotransferase
  15. IFCC Primary Reference Procedures for the Measurement of Catalytic Activity Concentrations of Enzymes at 37C. Part 6. Reference Procedure for the Measurement of Catalytic Concentration of γ-Glutamyltransferase
  16. IFCC Primary Reference Procedures for the Measurement of Catalytic Activity Concentrations of Enzymes at 37°C. Part 7. Certification of Four Reference Materials for the Determination of Enzymatic Activity of γ-Glutamyltransferase, Lactate Dehydrogenase, Alanine Aminotransferase and Creatine Kinase according to IFCC Reference Procedures at 37°C
  17. Clinical Biochemistry: Techniques and Instrumentation – a Practical Course. Edited by John S. Varcoe
  18. Meetings and Awards
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