Menopause, Coronary Artery Disease and Antioxidants
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Marija Krstevska
Abstract
The aim of this study was to examine the influence of menopause on the activity of primary intracellular antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx) as well as on the level of total antioxidant status (TAS) in healthy women and women with coronary artery disease (CAD). We studied 140 women divided into two groups. The first group (controls) consisted of 99 healthy women aged between 18 and 55 years) classified into three subgroups: premenopausal women (Pre-M; n=48), peri-menopausal women (Peri-M; n=22) and post-menopausal women (Post-M; n=29). The second group consisted of 41 women with CAD aged between 48–68 years, classified into two subgroups: Peri-M (n=20) and Post-M (n=21). The activity of GPx and the level of TAS were significantly decreased in Peri-M (p<0.005) and Post-M groups (p<0.001) in comparison with the Pre-M group. SOD was decreased in Peri-M and Post-M groups compared with the Pre-M group, but this was statistically not significant. The activity of SOD and GPx as well as TAS were significantly decreased in the Post-M group compared with the Peri-M group with CAD (p<0.001). The activity of the antioxidant enzymes in Peri-M and Post-M groups was significantly decreased (p<0.02) in comparison with the control group. TAS was not changed in women with CAD in comparison with controls. In conclusion, menopause leads to the reduction of the level of antioxidants, especially in women with CAD.
Copyright © 2001 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- The Impact of Cardiac Natriuretic Peptide Determination on the Diagnosis and Management of Heart Failure
- Models for Combining Random and Systematic Errors. Assumptions and Consequences for different Models
- Nucleosomes in Serum as a Marker for Cell Death
- Comparative Nuclear Magnetic Resonance Studies of Water Permeability of Red Blood Cells from Maternal Venous Blood and Newborn Umbilical Cord Blood
- Optimization of Single-Stranded Conformation Polymorphism (SSCP) Analysis for Screening for the Estrogen Receptor-α Gene Polymorphism P325P
- Serum Total Renin after Tubal Sterilization
- Oxidative Stress and Male IGF-1, Gonadotropin and Related Hormones in Diabetic Patients
- New PCR-Based Method for the Sp1 Site Polymorphism in the COL1A1 Gene
- Comparability of Serum and Plasma Concentrations of Haemostasis Activation Markers
- Importance of Validation of Immunoassays for Intact Proinsulin
- Plant Sterol-Enriched Margarine Lowers Plasma LDL in Hyperlipidemic Subjects with low Cholesterol Intake: Effect of Fibrate Treatment
- Menopause, Coronary Artery Disease and Antioxidants
- Arterial Tissue of Arsenic, Selenium and Iron in Blackfoot Disease Patients
- Evaluation of Aution Max AX-4280 Automated Urine Test-Strip Analyser
- Evaluation of Automated Enzyme Immunoassays for the Detection of Antibodies to Extractable Nuclear Antigens
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