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Remnant-Like Particle Cholesterol Levels in Korean Patients with Coronary Artery Disease and Non-Insulin Dependent Diabetes Mellitus

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Published/Copyright: June 1, 2005
Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 38 Issue 5

Abstract

Several studies have provided evidence that the remnants of lipoproteins may be the atherogenic components of triglyceride-rich lipoproteins. The purpose of this study was to investigate whether the remnant-like particle cholesterol (RLP-C) is an independent risk factor for coronary artery disease (CAD) and non-insulin dependent diabetes mellitus (NIDDM) in the Korean population and to explore the relationship between RLP-C and other biochemical markers as well as the apolipoprotein (apo) E genotypes. Lipid and lipoproteins including RLP-C and apo E genotypes were analyzed in 98 normal adults (control group), 68 patients with CAD (CAD group), 88 patients with NIDDM (DM group), and 19 patients with both CAD and NDDM (CAD + DM group). RLP-C levels were significantly higher in the DM (p< 0.0001), CAD (p = 0.0012) and the CAD + DM groups (p = 0.0184) than in the controls. To determine which variable could discriminate most effectively and independently among the different groups, stepwise linear discriminant analysis was performed for all the variables that showed p< 0.15 by unvariate analysis. RLP-C was selected as an independent discriminator between the control and patient groups. RLP-C levels showed a strong positive correlation with trigylceride levels in the control, CAD and DM groups (r= 0.783, r = 0.610 and r= 0.746, respectively). In overall groups, apo ε4 and ε2 carrier genotypes showed a significant increase in RLP-C levels compared with ∊3/3 wild-type (p = 0.0085). After adjusting for the effect of apo E genotypes, a significant increase of the RLP-C levels in the disease groups remained. In conclusion, RLP-C was determined to be an independent risk factor in Korean patients with CAD and NIDDM and showed a strong correlation with triglyceride levels. We suggest that the increased cardiovascular risk associated with the ε4 and ε2 allele may be mediated by more atherogenic RLP-C.

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Published Online: 2005-06-01
Published in Print: 2000-05-21

Copyright © 2000 by Walter de Gruyter GmbH & Co. KG

Articles in the same Issue

  1. Large Differences in Laboratory Utilisation between Hospitals in Sweden
  2. Development of a Method for Rapid Quantitation of Amino Acids by Liquid Chromatography-Tandem Mass Spectrometry (LC-MSMS) in Plasma
  3. Adhesion Molecule Behavior during Rejection and Infection Episodes after Heart Transplantation
  4. The Activity of Class I and II Alcohol Dehydrogenase Isoenzymes in the Sera of Patients with Liver Tumours
  5. Association between PON1 L/M55 Polymorphism and Plasma Lipoproteins in Two Canadian Aboriginal Populations
  6. Concentration of Lp(a) and other Apolipoproteins in Predialysis, Hemodialysis, Chronic Ambulatory Peritoneal Dialysis and Post-Transplant Patients
  7. Remnant-Like Particle Cholesterol Levels in Korean Patients with Coronary Artery Disease and Non-Insulin Dependent Diabetes Mellitus
  8. Red Blood Cell Osmotic Fragility Confidence Intervals: a Definition by Application of a Mathematical Model
  9. Assessment of Iron Status with a New Fully Automated Assay for Transferrin Receptor in Human Serum
  10. Alterations in Laboratory Test Results during Adjuvant Breast Cancer Treatment
  11. Assessment of CA 15.3, CEA and TPA Concentrations during Monitoring of Breast Cancer
  12. Evaluation of a Newly Available Biochemical Analyzer: the Olympus AU 600
  13. Association between Apolipoprotein E Alleles and Autoantibodies against Oxidised Low-Density Lipoprotein
  14. ALP Isoenzyme Separation in Type 1 Gaucher Disease
  15. Handbook of the Biology of Aging. By Edward L. Schneider and John W. Rowe, editors
  16. Understanding Acid-Base Disorders. Clinical Acid-Base Balance. By W. S. T. Thomson, J. F. Adams and R. A. Cowan
https://doi.org/10.1515/CCLM.2000.062

Articles in the same Issue

  1. Large Differences in Laboratory Utilisation between Hospitals in Sweden
  2. Development of a Method for Rapid Quantitation of Amino Acids by Liquid Chromatography-Tandem Mass Spectrometry (LC-MSMS) in Plasma
  3. Adhesion Molecule Behavior during Rejection and Infection Episodes after Heart Transplantation
  4. The Activity of Class I and II Alcohol Dehydrogenase Isoenzymes in the Sera of Patients with Liver Tumours
  5. Association between PON1 L/M55 Polymorphism and Plasma Lipoproteins in Two Canadian Aboriginal Populations
  6. Concentration of Lp(a) and other Apolipoproteins in Predialysis, Hemodialysis, Chronic Ambulatory Peritoneal Dialysis and Post-Transplant Patients
  7. Remnant-Like Particle Cholesterol Levels in Korean Patients with Coronary Artery Disease and Non-Insulin Dependent Diabetes Mellitus
  8. Red Blood Cell Osmotic Fragility Confidence Intervals: a Definition by Application of a Mathematical Model
  9. Assessment of Iron Status with a New Fully Automated Assay for Transferrin Receptor in Human Serum
  10. Alterations in Laboratory Test Results during Adjuvant Breast Cancer Treatment
  11. Assessment of CA 15.3, CEA and TPA Concentrations during Monitoring of Breast Cancer
  12. Evaluation of a Newly Available Biochemical Analyzer: the Olympus AU 600
  13. Association between Apolipoprotein E Alleles and Autoantibodies against Oxidised Low-Density Lipoprotein
  14. ALP Isoenzyme Separation in Type 1 Gaucher Disease
  15. Handbook of the Biology of Aging. By Edward L. Schneider and John W. Rowe, editors
  16. Understanding Acid-Base Disorders. Clinical Acid-Base Balance. By W. S. T. Thomson, J. F. Adams and R. A. Cowan
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