Skip to main content
Article
Licensed
Unlicensed Requires Authentication

The Activity of Class I and II Alcohol Dehydrogenase Isoenzymes in the Sera of Patients with Liver Tumours

  • and
Published/Copyright: June 1, 2005
Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 38 Issue 5

Abstract

We have measured the activity of class I and II alcohol dehydrogenase isoenzymes in the sera of patients with liver tumours, using class-specific fluorogenic naphthaldehydes as substrates. The activity of the tested isoenzymes was unchanged in primary tumours and significantly increased (class I) in metastatic liver tumours. The total enzyme activity was also increased (3-fold) in this group of patients. The elevated activity of class I isoenzymes in secondary tumours seems to be caused by the enzyme released from primary cells originating in the other organs, but increased total enzyme activity measured with chromogenic substrates may be proof of the presence of other classes of isoenzymes. These results show that the elevated class I isoenzymes and total enzyme activity in the sera of patients with liver tumours may indicate the metastatic origin of these tumours.

:
Published Online: 2005-06-01
Published in Print: 2000-05-21

Copyright © 2000 by Walter de Gruyter GmbH & Co. KG

Articles in the same Issue

  1. Large Differences in Laboratory Utilisation between Hospitals in Sweden
  2. Development of a Method for Rapid Quantitation of Amino Acids by Liquid Chromatography-Tandem Mass Spectrometry (LC-MSMS) in Plasma
  3. Adhesion Molecule Behavior during Rejection and Infection Episodes after Heart Transplantation
  4. The Activity of Class I and II Alcohol Dehydrogenase Isoenzymes in the Sera of Patients with Liver Tumours
  5. Association between PON1 L/M55 Polymorphism and Plasma Lipoproteins in Two Canadian Aboriginal Populations
  6. Concentration of Lp(a) and other Apolipoproteins in Predialysis, Hemodialysis, Chronic Ambulatory Peritoneal Dialysis and Post-Transplant Patients
  7. Remnant-Like Particle Cholesterol Levels in Korean Patients with Coronary Artery Disease and Non-Insulin Dependent Diabetes Mellitus
  8. Red Blood Cell Osmotic Fragility Confidence Intervals: a Definition by Application of a Mathematical Model
  9. Assessment of Iron Status with a New Fully Automated Assay for Transferrin Receptor in Human Serum
  10. Alterations in Laboratory Test Results during Adjuvant Breast Cancer Treatment
  11. Assessment of CA 15.3, CEA and TPA Concentrations during Monitoring of Breast Cancer
  12. Evaluation of a Newly Available Biochemical Analyzer: the Olympus AU 600
  13. Association between Apolipoprotein E Alleles and Autoantibodies against Oxidised Low-Density Lipoprotein
  14. ALP Isoenzyme Separation in Type 1 Gaucher Disease
  15. Handbook of the Biology of Aging. By Edward L. Schneider and John W. Rowe, editors
  16. Understanding Acid-Base Disorders. Clinical Acid-Base Balance. By W. S. T. Thomson, J. F. Adams and R. A. Cowan
https://doi.org/10.1515/CCLM.2000.059

Articles in the same Issue

  1. Large Differences in Laboratory Utilisation between Hospitals in Sweden
  2. Development of a Method for Rapid Quantitation of Amino Acids by Liquid Chromatography-Tandem Mass Spectrometry (LC-MSMS) in Plasma
  3. Adhesion Molecule Behavior during Rejection and Infection Episodes after Heart Transplantation
  4. The Activity of Class I and II Alcohol Dehydrogenase Isoenzymes in the Sera of Patients with Liver Tumours
  5. Association between PON1 L/M55 Polymorphism and Plasma Lipoproteins in Two Canadian Aboriginal Populations
  6. Concentration of Lp(a) and other Apolipoproteins in Predialysis, Hemodialysis, Chronic Ambulatory Peritoneal Dialysis and Post-Transplant Patients
  7. Remnant-Like Particle Cholesterol Levels in Korean Patients with Coronary Artery Disease and Non-Insulin Dependent Diabetes Mellitus
  8. Red Blood Cell Osmotic Fragility Confidence Intervals: a Definition by Application of a Mathematical Model
  9. Assessment of Iron Status with a New Fully Automated Assay for Transferrin Receptor in Human Serum
  10. Alterations in Laboratory Test Results during Adjuvant Breast Cancer Treatment
  11. Assessment of CA 15.3, CEA and TPA Concentrations during Monitoring of Breast Cancer
  12. Evaluation of a Newly Available Biochemical Analyzer: the Olympus AU 600
  13. Association between Apolipoprotein E Alleles and Autoantibodies against Oxidised Low-Density Lipoprotein
  14. ALP Isoenzyme Separation in Type 1 Gaucher Disease
  15. Handbook of the Biology of Aging. By Edward L. Schneider and John W. Rowe, editors
  16. Understanding Acid-Base Disorders. Clinical Acid-Base Balance. By W. S. T. Thomson, J. F. Adams and R. A. Cowan
Downloaded on 21.4.2026 from https://www.degruyterbrill.com/document/doi/10.1515/CCLM.2000.059/html
Scroll to top button