Oxidized Low Density Lipoprotein: Atherogenic and Proinflammatory Characteristics during Macrophage Foam Cell Formation. An Inhibitory Role for Nutritional Antioxidants and Serum Paraoxonase
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Marielle Kaplan
Abstract
Oxidative stress and inflammatory processes are of major importance in atherogenesis because they stimulate oxidized LDL (Ox-LDL)-induced macrophage cholesterol accumulation and foam cell formation, the hallmark of early atherosclerosis. Under oxidative stress, both blood monocytes and plasma lipoproteins invade the arterial wall, where they are exposed to atherogenic modifications. Oxidative stress stimulates endothelial secretion of monocyte chemoattractant protein 1 (MCP-1) and of macrophage colony stimulating factor (M-CSF), leading to monocyte adhesion and differentiation, respectively. LDL binds to extracellular matrix (ECM secreted by endothelial cells, smooth muscle cells and macrophages) proteoglycans, in a process that contributes to the enhanced susceptibility of the lipoprotein to oxidation by arterial wall macrophages. ECM-retained Ox-LDL is taken up by activated macrophages via their scavenger receptors. This leads to cellular cholesterol accumulation and enhanced atherogenesis. Protection of LDL against oxidation by antioxidants that can act directly on the LDL, or indirectly on the cellular oxidative machinery, or conversion of Ox-LDL to a non-atherogenic particle by HDL-associated paraoxonase (PON-1), can contribute to attenuation of atherosclerosis.
Copyright © 1999 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- Oxidized Low Density Lipoprotein: Atherogenic and Proinflammatory Characteristics during Macrophage Foam Cell Formation. An Inhibitory Role for Nutritional Antioxidants and Serum Paraoxonase
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- Urinary Porphyrin Excretion in Hepatitis C Infection
- Quantification of Low Abundance Natriuretic Peptide Receptor mRNA in Rat Tissues
- Rat Tissue Collagen Modified by Advanced Glycation: Correlation with Duration of Diabetes and Glycemic Control
- Reference Values for a Homogeneous Ferritin Assay and Traceability to the 3rd International Recombinant Standard for Ferritin (NIBSC Code 94/572)
- Iron Saturation of Ferritin in the Course of Phlebotomy Treatment in Patients with Haemochromatosis
- Neural Networks for the Biochemical Prediction of Bone Mass Loss
- Serum Dipeptidyl Peptidase IV Activity Correlates with the T-Cell CD26 Antigen
- The Baltic Atherosclerosis Journal
- Concise Biochemistry, by Anatol Bezkorovainy and Max E. Rafelson Jr.
- Cytokines in Severe Sepsis and Septic Shock, by H. Redl and G. Schlag
Articles in the same Issue
- Oxidized Low Density Lipoprotein: Atherogenic and Proinflammatory Characteristics during Macrophage Foam Cell Formation. An Inhibitory Role for Nutritional Antioxidants and Serum Paraoxonase
- Molecular Aspects and Natural Source of Procalcitonin
- Urinary Porphyrin Excretion in Hepatitis C Infection
- Quantification of Low Abundance Natriuretic Peptide Receptor mRNA in Rat Tissues
- Rat Tissue Collagen Modified by Advanced Glycation: Correlation with Duration of Diabetes and Glycemic Control
- Reference Values for a Homogeneous Ferritin Assay and Traceability to the 3rd International Recombinant Standard for Ferritin (NIBSC Code 94/572)
- Iron Saturation of Ferritin in the Course of Phlebotomy Treatment in Patients with Haemochromatosis
- Neural Networks for the Biochemical Prediction of Bone Mass Loss
- Serum Dipeptidyl Peptidase IV Activity Correlates with the T-Cell CD26 Antigen
- The Baltic Atherosclerosis Journal
- Concise Biochemistry, by Anatol Bezkorovainy and Max E. Rafelson Jr.
- Cytokines in Severe Sepsis and Septic Shock, by H. Redl and G. Schlag
