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Lactoferrin: A Multifunctional Glycoprotein Involved in the Modulation of the Inflammatory Process

  • Sophie Baveye , Elisabeth Elass , Joël Mazurier , Geneviève Spik and Dominique Legrand
Published/Copyright: June 1, 2005
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Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 37 Issue 3

Abstract

Lactoferrin is an iron-binding glycoprotein found in exocrine secretions of mammals and released from neutrophilic granules during inflammation. This review describes the biological roles of lactoferrin in host defence. Secreted lactoferrin exerts antimicrobial action either by chelation of iron or by destabilization of bacterial membranes. Furthermore, lactoferrin modulates the inflammatory process, mainly by preventing the release of cytokines from monocytes and by regulating the proliferation and differentiation of immune cells. Some of these activities are related to the ability of lactoferrin to bind lipopolysaccharides (LPS) with high affinity. Indeed, recent in vitro studies indicate that lactoferrin is able to compete with the LPS-binding protein for LPS binding and therefore to prevent the transfer of LPS to CD14 present at the surface of monocytes. Moreover, the prophylactic properties of lactoferrin against septicemia in vivo have been demonstrated. Taken as a whole, these observations strongly suggest that lactoferrin is one of the key molecules which modulate the inflammatory response.

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Published Online: 2005-06-01
Published in Print: 1999-03-01

Copyright (c)1999 by Walter de Gruyter GmbH & Co. KG

Articles in the same Issue

  1. IFCC/Beckman European Conference 1998 Frontiers in Molecular Basis of Disease: Inflammatory Diseases
  2. Frontiers in Molecular Basis of Disease: Inflammatory Diseases
  3. Mechanisms of Antigen Presentation
  4. How to Extinguish Lymphocyte Activation, Immunotyrosine-Based Inhibition Motif (ITIM)-Bearing Molecules a Solution?
  5. Association between Reduced Human Leukocyte Antigen (HLA)-DR Expression on Blood Monocytes and Increased Plasma Level of Interleukin-10 in Patients with Severe Burns
  6. Immunostimulatory CpG Motifs Trigger a T Helper-1 Immune Response to Human Immunodeficiency Virus Type-1 (HIV-1) gp160 Envelope Proteins
  7. Activation and Regulation of NFκB during Acute Inflammation
  8. CD 14++ Monocytes, CD14+/CD16+ Subset and Soluble CD14 as Biological Markers of Inflammatory Systemic Diseases and Monitoring Immuno-suppressive Therapy
  9. A Potential Role of an Intracellular Signaling Defect in Neutrophil Functional Abnormalities and Promotion of Tissue Damage in Patients with Localized Juvenile Periodontitis
  10. Polymorphonuclear Oxidative Burst after Helicobacter pylori Water Extract Stimulation Is not Influenced by the Cytotoxic Genotype but Indicates Infection and Gastritis Grade
  11. Flow Cytometry of Cerebrospinal Fluid (CSF) Lymphocytes: Alterations of Blood/CSF Ratios of Lymphocyte Subsets in Inflammation Disorders of Human Central Nervous System (CNS)
  12. Effects of Oxidized Low Density Lipoprotein, Lipid Mediators and Statins on Vascular Cell Interactions
  13. Mycophenolic Acid Influences T Helper 2 (Th2) Cytokine Induced Expression of Intercellular Cell Adhesion Molecule -1 (ICAM-1) on Human Endothelial Cells
  14. Alterations of Endothelial Nucleotide Levels by Mycophenolic Acid Result in Changes of Membrane Glycosylation and E-Selectin Expression
  15. C-Reactive Protein: Structural Biology and Host Defense Function
  16. A Novel Acute-Phase Marker: Lipopolysaccharide Binding Protein (LBP)
  17. Detection of Acute Phase Response and Infection. The Role of Procalcitonin and C-Reactive Protein
  18. Lactoferrin: A Multifunctional Glycoprotein Involved in the Modulation of the Inflammatory Process
  19. Annexin V and Phospholipid Metabolism
  20. Regulation of Leukocyte Trafficking by Lipoxins
  21. Lipoxin and Aspirin-Triggered 15-epi-Lipoxin Cellular Interactions Anti-Inflammatory Lipid Mediators
  22. Differentiation and Assessment of Cell Death
  23. Depending on Their Concentration Oxidized Low Density Lipoproteins Stimulate Extracellular Matrix Synthesis or Induce Apoptosis in Human Coronary Artery Smooth Muscle Cells
  24. Apheresis of Plasma Compounds as a Therapeutic Principle in Severe Sepsis and Multiorgan Dysfunction Syndrome
  25. Supportive Therapy of the Sepsis Syndrome
  26. Supplemental Immune Globulins in Sepsis
  27. Polymorphonuclear Granulocyte Stimulation by Cellulose-Based Hemodialysis Membranes
  28. Reduction of Circulating Cholesterol and Apolipoprotein Levels during Sepsis
  29. Outcome Prediction by Traditional and New Markers of Inflammation in Patients with Sepsis
  30. Isolation of Highly Enriched Human Monocytes from Ten ml Samples of Heparinised Whole Blood
  31. Endotoxin Adsorbant Based on Immobilized Human Serum Albumin
https://doi.org/10.1515/CCLM.1999.049

Articles in the same Issue

  1. IFCC/Beckman European Conference 1998 Frontiers in Molecular Basis of Disease: Inflammatory Diseases
  2. Frontiers in Molecular Basis of Disease: Inflammatory Diseases
  3. Mechanisms of Antigen Presentation
  4. How to Extinguish Lymphocyte Activation, Immunotyrosine-Based Inhibition Motif (ITIM)-Bearing Molecules a Solution?
  5. Association between Reduced Human Leukocyte Antigen (HLA)-DR Expression on Blood Monocytes and Increased Plasma Level of Interleukin-10 in Patients with Severe Burns
  6. Immunostimulatory CpG Motifs Trigger a T Helper-1 Immune Response to Human Immunodeficiency Virus Type-1 (HIV-1) gp160 Envelope Proteins
  7. Activation and Regulation of NFκB during Acute Inflammation
  8. CD 14++ Monocytes, CD14+/CD16+ Subset and Soluble CD14 as Biological Markers of Inflammatory Systemic Diseases and Monitoring Immuno-suppressive Therapy
  9. A Potential Role of an Intracellular Signaling Defect in Neutrophil Functional Abnormalities and Promotion of Tissue Damage in Patients with Localized Juvenile Periodontitis
  10. Polymorphonuclear Oxidative Burst after Helicobacter pylori Water Extract Stimulation Is not Influenced by the Cytotoxic Genotype but Indicates Infection and Gastritis Grade
  11. Flow Cytometry of Cerebrospinal Fluid (CSF) Lymphocytes: Alterations of Blood/CSF Ratios of Lymphocyte Subsets in Inflammation Disorders of Human Central Nervous System (CNS)
  12. Effects of Oxidized Low Density Lipoprotein, Lipid Mediators and Statins on Vascular Cell Interactions
  13. Mycophenolic Acid Influences T Helper 2 (Th2) Cytokine Induced Expression of Intercellular Cell Adhesion Molecule -1 (ICAM-1) on Human Endothelial Cells
  14. Alterations of Endothelial Nucleotide Levels by Mycophenolic Acid Result in Changes of Membrane Glycosylation and E-Selectin Expression
  15. C-Reactive Protein: Structural Biology and Host Defense Function
  16. A Novel Acute-Phase Marker: Lipopolysaccharide Binding Protein (LBP)
  17. Detection of Acute Phase Response and Infection. The Role of Procalcitonin and C-Reactive Protein
  18. Lactoferrin: A Multifunctional Glycoprotein Involved in the Modulation of the Inflammatory Process
  19. Annexin V and Phospholipid Metabolism
  20. Regulation of Leukocyte Trafficking by Lipoxins
  21. Lipoxin and Aspirin-Triggered 15-epi-Lipoxin Cellular Interactions Anti-Inflammatory Lipid Mediators
  22. Differentiation and Assessment of Cell Death
  23. Depending on Their Concentration Oxidized Low Density Lipoproteins Stimulate Extracellular Matrix Synthesis or Induce Apoptosis in Human Coronary Artery Smooth Muscle Cells
  24. Apheresis of Plasma Compounds as a Therapeutic Principle in Severe Sepsis and Multiorgan Dysfunction Syndrome
  25. Supportive Therapy of the Sepsis Syndrome
  26. Supplemental Immune Globulins in Sepsis
  27. Polymorphonuclear Granulocyte Stimulation by Cellulose-Based Hemodialysis Membranes
  28. Reduction of Circulating Cholesterol and Apolipoprotein Levels during Sepsis
  29. Outcome Prediction by Traditional and New Markers of Inflammation in Patients with Sepsis
  30. Isolation of Highly Enriched Human Monocytes from Ten ml Samples of Heparinised Whole Blood
  31. Endotoxin Adsorbant Based on Immobilized Human Serum Albumin
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