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Phospholipases A2 in Gastric Juice of Helicobacter pylori – Positive and Negative Individuals

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Published/Copyright: June 1, 2005
Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 37 Issue 1

Abstract

Gastric juice is known to have phospholipase A2 catalytic activity. Helicobacter pylori (H. pylori) has been reported to produce phospholipase A2, which is believed to hydrolyse the protective layer of gastric mucosal phospholipids and to promote mucosal damage. The current study aimed at identifying secretory phospholipase A2 subtypes (pancreatic group I phospholipase A2 and synovial-type group II phospholipase A2) in gastric juice and their relation to the presence of H. pyloriin gastric mucosal biopsies in the same individuals. Gastric juice was collected from 29 individuals during gastroscopy. Biopsies were taken from the antrum and body of the stomach to determine the H. pylori status. We found catalytically active phospholipase A2 and both group I and group II phospholipases A2 in the gastric juice samples. The catalytic activity and the mass concentrations of group I and group II phospholipases A2 correlated significantly with the pH value in gastric juice. The gastric juice of H. pylori positive individuals did not contain higher amounts of phospholipases A2 than the juice of H. pylori negative individuals. Rather, the mass concentration of group II phospholipase A2 in gastric juice seemed to be somewhat lower in individuals with H. pylori infection than in uninfected individuals. The results of the current study show that both group I and group II phospholipases A2 are present in gastric juice. The main sources of phospholipases A2 in gastric juice are probably other than H. pylori.

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Published Online: 2005-06-01
Published in Print: 1999-01-01

Copyright (c)1999 by Walter de Gruyter GmbH & Co. KG

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  1. Structure, Function and Clinical Significance of Transferrin Receptors
  2. Cardiac Troponin I and Troponin T: Recent Players in the Field of Myocardial Markers
  3. Determination of Free Apolipoprotein(a) in Serum by Immunoassay and Its Significance for Risk Assessment in Patients with Coronary Artery Disease
  4. Fecal Tumor Necrosis Factor alpha, Eosinophil Cationic Protein and IgE Levels in Infants with Cows Milk Allergy and Gastrointestinal Manifestations
  5. Detection of GB Virus C/Hepatitis G Virus RNA by Reverse-Transcription Polymerase Chain Reaction
  6. Development of Capillary Electrophoresis as An Alternative to High Resolution Agarose Electrophoresis for the Diagnosis of Multiple Sclerosis
  7. Urokinase and Plasminogen Activator-Inhibitor (PAI-1) Status in Primary Ovarian Carcinomas and Ovarian Metastases Compared to Benign Ovarian Tumors as A Function of Histopathological Parameters
  8. Intracellular and Extracellular, Ionized and Total Magnesium in Pre-Eclampsia and Uncomplicated Pregnancy
  9. Phospholipases A2 in Gastric Juice of Helicobacter pylori – Positive and Negative Individuals
  10. Appropriateness of Physicians Requests of Laboratory Examinations in Primary Health Care: An Over- and Under-Utilisation Study
  11. Effect of the Hemoglobin-Based Oxygen Carrier HBOC-201 on Laboratory Instrumentation: Cobas Integra, Chiron Blood Gas Analyzer 840, Sysmex™SE-9000 and BCT
  12. Current System of Undergraduate and Postgraduate Education in Clinical Chemistry in Croatia
  13. The Effects of Fasting on Blood Antioxidant Potential and Malondialdehyde Levels
  14. Biological Variation in Lipoprotein(a)
  15. Molecular Biology or Steroid and Nuclear Hormone Receptors by Leonard P. Freedman, editor
https://doi.org/10.1515/CCLM.1999.009

Articles in the same Issue

  1. Structure, Function and Clinical Significance of Transferrin Receptors
  2. Cardiac Troponin I and Troponin T: Recent Players in the Field of Myocardial Markers
  3. Determination of Free Apolipoprotein(a) in Serum by Immunoassay and Its Significance for Risk Assessment in Patients with Coronary Artery Disease
  4. Fecal Tumor Necrosis Factor alpha, Eosinophil Cationic Protein and IgE Levels in Infants with Cows Milk Allergy and Gastrointestinal Manifestations
  5. Detection of GB Virus C/Hepatitis G Virus RNA by Reverse-Transcription Polymerase Chain Reaction
  6. Development of Capillary Electrophoresis as An Alternative to High Resolution Agarose Electrophoresis for the Diagnosis of Multiple Sclerosis
  7. Urokinase and Plasminogen Activator-Inhibitor (PAI-1) Status in Primary Ovarian Carcinomas and Ovarian Metastases Compared to Benign Ovarian Tumors as A Function of Histopathological Parameters
  8. Intracellular and Extracellular, Ionized and Total Magnesium in Pre-Eclampsia and Uncomplicated Pregnancy
  9. Phospholipases A2 in Gastric Juice of Helicobacter pylori – Positive and Negative Individuals
  10. Appropriateness of Physicians Requests of Laboratory Examinations in Primary Health Care: An Over- and Under-Utilisation Study
  11. Effect of the Hemoglobin-Based Oxygen Carrier HBOC-201 on Laboratory Instrumentation: Cobas Integra, Chiron Blood Gas Analyzer 840, Sysmex™SE-9000 and BCT
  12. Current System of Undergraduate and Postgraduate Education in Clinical Chemistry in Croatia
  13. The Effects of Fasting on Blood Antioxidant Potential and Malondialdehyde Levels
  14. Biological Variation in Lipoprotein(a)
  15. Molecular Biology or Steroid and Nuclear Hormone Receptors by Leonard P. Freedman, editor
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