Long-Term Variability of Serum Lipoprotein(a) Concentrations in Healthy Fertile Women
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Roselyne Garnotel
Abstract
Lipoprotein(a) is a unique lipoprotein with atherothrombogenic properties. Although its blood concentration is mainly genetically determined, various factors exist which may cause variability. These may influence the clinical use of the results. We studied lipoprotein(a) biological variation by a rate nephelometric assay over a period of two years in a population of healthy fertile women. The study was performed in 12 volunteers, healthy subjects with various lipoprotein( a) concentrations, by monthly determinations during one year and a single determination one year later, together with measurements of total, high density lipoprotein and high density lipoprotein2 cholesterol, triglycerides and apolipoproteins A1 and B. The intra-individual variability of lipoprotein(a) ranged between 4 to 20%, with three subjects showing a coefficient of biological variation higher than 15 %. In absolute terms, the difference between two determinations could represent 0.44 g/l or 50 % of the mean value. This study suggests that physiological lipoprotein( a) variations should be taken into account for clinical purposes, especially in patients in need of thorough risk evaluation.
Copyright © 1999 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Developments in Quantitative PCR
- Endemic Nephropathy in Croatia
- Mutation Analysis of Exon 3 of the LDL Receptor Gene in Patients with Severe Hypercholesterolemia
- Recombinant Human Heart-Type Fatty Acid-Binding Protein as Standard in Immunochemical Assays
- Sialic Acid, Transketolase and Na+, K+, ATPase in Patients with Rheumatoid Arthritis
- Quantitation and Enzymatic Activity of the Alkaline Protease from Pseudomonas aeruginosa in Culture Supernatants from Clinical Strains
- Preparation of a Candidate Primary Reference Material for the International Standardisation of HbA1c Determinations
- Urinary α1-Microglobulin Detects Uropathy. A Prospective Study in 483 Urological Patients
- Long-Term Variability of Serum Lipoprotein(a) Concentrations in Healthy Fertile Women
- Short-Term Variability in the Concentration of Serum Interleukin-6 and Its Soluble Receptor in Subjectively Healthy Persons
- Pediatric Reference Intervals for 34 Biochemical Analytes in Urban School Children and Adolescents
