Sialic Acid, Transketolase and Na+, K+, ATPase in Patients with Rheumatoid Arthritis
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Abstract
We studied transketolase activity of red blood cell hemolysates, and Na+, K+, ATPase activity and sialic acid concentration in red blood cell membranes from 52 patients with rheumatoid arthritis and 24 control subjects. Decreased red blood cell membrane Na+, K+, ATPase activity and sialic acid concentration and decreased transketolase in red blood cell hemolysates were observed in rheumatoid arthritis patients compared with control subjects (p < 0.001). Erythrocyte sedimentation rate and C-reactive protein values were increased in rheumatoid arthritis patients compared with control subjects (p < 0.0001). Significant correlations between sialic acid and Na+, K+, ATPase (r = 0.65, p < 0.001) and between sialic acid and transketolase (r = 0.58, p < 0.001) were observed. Erythrocyte sedimentation rate and C-reactive protein levels did not correlate with Na+, K+, ATPase activity or with sialic acid or transketolase in rheumatoid arthritis patients.
These data show that decreases in Na+, K+, ATPase, and transketolase activities and sialic acid concentration are present in rheumatoid arthritis patients, and that the decrease in Na+, K+, ATPase and transketolase activities in rheumatoid arthritis might be due to decreased sialic acid.
Copyright © 1999 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Developments in Quantitative PCR
- Endemic Nephropathy in Croatia
- Mutation Analysis of Exon 3 of the LDL Receptor Gene in Patients with Severe Hypercholesterolemia
- Recombinant Human Heart-Type Fatty Acid-Binding Protein as Standard in Immunochemical Assays
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- Quantitation and Enzymatic Activity of the Alkaline Protease from Pseudomonas aeruginosa in Culture Supernatants from Clinical Strains
- Preparation of a Candidate Primary Reference Material for the International Standardisation of HbA1c Determinations
- Urinary α1-Microglobulin Detects Uropathy. A Prospective Study in 483 Urological Patients
- Long-Term Variability of Serum Lipoprotein(a) Concentrations in Healthy Fertile Women
- Short-Term Variability in the Concentration of Serum Interleukin-6 and Its Soluble Receptor in Subjectively Healthy Persons
- Pediatric Reference Intervals for 34 Biochemical Analytes in Urban School Children and Adolescents
