Seaweed polysaccharides with anticancer potential
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Hui Wang
Abstract
Aqueous extracts from 12 species of Hong Kong seaweeds were screened for their antiproliferative potential on HL-60 and MCF-7 cell lines. Eight seaweeds exhibited selective antiproliferative activity on HL-60 cells, while 10 species possessed some effect on MCF-7 cell line. Two brown seaweeds, Hydroclathrus clathratus and Padina arborescenos, had a higher inhibitory effect on the growth of both cancer cell lines than the others and were less toxic to normal cells. The extract of H. clathratus (Hy) caused morphological alteration of MCF-7 cells when they were treated at the beginning of incubation. Some polysaccharide fractions isolated and purified from Hy had antiproliferative activity on both HL-60 and MCF-7 cell lines. Furthermore, all of these fractions, including the crude extract, had varying degrees of antioxidant activity. In vivo antitumor tests using Sarcoma 180 tumor-bearing BALB/c mice showed that the fraction H3-a from H. clathratus had the best effect in suppressing tumor growth in the treated mice.
©2008 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Review
- Alien marine macrophytes in Greece: a review
- Research articles
- Effects of erosion and macroalgae on intertidal eelgrass (Zostera marina) in a northeastern Pacific estuary (USA)
- A reassessment of Halophila species (Hydrocharitaceae) diversity with special reference to Japanese representatives
- Survey and phytochemical analysis of seagrasses in the Gulf of Mannar, southeast coast of India
- Temperature response in a shallow-water Mediterranean population of Caulerpa racemosa var. cylindracea (Caulerpales, Chlorophyta), and a possible strategy of season anticipation
- Dynamics and patterns of algal colonization on mechanically damaged and dead colonies of the coral Porites lutea
- Toxicity, morphology and distribution of Pseudo-nitzschia calliantha, P. multistriata and P. multiseries (Bacillariophyta) from the northwestern Sea of Japan
- Ceramium periconicum sp. nov. (Ceramiaceae, Rhodophyta): a new subtidal species from Baja California Sur, Mexico
- Seaweed polysaccharides with anticancer potential
- Iron, zinc, copper, lead and cadmium contents in Ruppia maritima from a Mediterranean coastal lagoon: monthly variation and distribution in different plant fractions
- Taxonomy and molecular phylogeny of Arthrobotrys mangrovispora, a new marine nematode-trapping fungal species
- Meetings
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