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Epidermal growth factor receptor signaling in liver cell proliferation and apoptosis
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Roland Reinehr
Published/Copyright:
June 27, 2009
Abstract
Recent evidence suggests that epidermal growth factor receptor (EGFR)-dependent signaling contributes to liver cell proliferation, as well as to apoptotic liver cell death, and represents an important regulator of hepatic regeneration. This article summarizes recent findings on the molecular mechanisms involved in EGFR-mediated cell proliferation and apoptosis. The emphasis is on the interplay between EGFR and CD95 (Fas, APO-1) death receptor-signaling, which is determined by the signaling context and liver cell type investigated.
Keywords: acidic sphingomyelinase (ASM); CD95 (Fas, APO-1); c-Jun-N-terminal kinase (JNK); NADPH oxidase (NOX); reactive oxygen species (ROS); Src family kinase Yes
Received: 2009-3-22
Accepted: 2009-5-11
Published Online: 2009-06-27
Published in Print: 2009-10-01
©2009 by Walter de Gruyter Berlin New York
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Keywords for this article
acidic sphingomyelinase (ASM);
CD95 (Fas, APO-1);
c-Jun-N-terminal kinase (JNK);
NADPH oxidase (NOX);
reactive oxygen species (ROS);
Src family kinase Yes
Articles in the same Issue
- Guest Editorial
- Highlight: ‘Regenerative Hepatology’
- Highlight: Regenerative Hepatology
- The do's and don'ts of p53 isoforms
- Mechanisms of liver disease: cross-talk between the NF-κB and JNK pathways
- Immunologic hurdles of therapeutic stem cell transplantation
- Ancestral vascular tube formation and its adoption by tumors
- Cellular plasticity of the pancreas
- Hepatic and pancreatic stellate cells in focus
- Interplay between host cell and hepatitis C virus in regulating viral replication
- Epidermal growth factor receptor signaling in liver cell proliferation and apoptosis
- The chemokine scavenging receptor D6 limits acute toxic liver injury in vivo
- Hepatic differentiation of pluripotent stem cells
- Protein Structure and Function
- Effect of curcumin on amyloidogenic property of molten globule-like intermediate state of 2,5-diketo-d-gluconate reductase A
- Cell Biology and Signaling
- Specific induction of migration and invasion of pancreatic carcinoma cells by RhoC, which differs from RhoA in its localisation and activity
- Autoregulatory control of the p53 response by Siah-1L-mediated HIPK2 degradation
