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Cross talk between kinin and angiotensin II receptors in mouse abdominal aorta

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Published/Copyright: May 20, 2009
Biological Chemistry
From the journal Volume 390 Issue 9

Abstract

Bradykinin (BK) is a vasorelaxant, algesic and inflammatory agent. Angiotensin II (AngII) is known to control vascular tone and promote growth, inflammation and artherogenesis. There is evidence for cross talking between BK and AngII receptors. Therefore, the effect of lack of kinin receptors was assessed in mice with genetic disruption of B1 or B2 and both receptors. Responsiveness of abdominal aortic rings to BK and AngII as well as the receptor gene expression of both peptides were analysed. Although no specific phenotype was displayed in the normotensive and healthy mice lacking the kinin receptors, a decreased expression level of the remaining kinin receptor mRNA was observed. AT1 receptor mRNA level was also reduced, indicating that kinin receptors regulate AngII receptors. Downregulation of the receptors was well correlated with reduction in the reactivity of both agonists to induce contraction of aortic rings, but other signal regulations must be sought in these transgenic mice. We conclude that cross talk between kinin and AngII receptors occurs in mouse abdominal aorta and that both peptides may regulate the initiation and progression of important pathophysiological processes, such as hypertension and inflammation.

Keywords: angiotensin II; bradykinin; cross talk; kinin receptor-deficient mice
Corresponding author
Received: 2009-1-9
Accepted: 2009-4-15
Published Online: 2009-05-20
Published in Print: 2009-09-01

©2009 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/BC.2009.081
Keywords for this article
angiotensin II; bradykinin; cross talk; kinin receptor-deficient mice

Articles in the same Issue

  1. Review
  2. Dimeric/oligomeric DNA methyltransferases: an unfinished story
  3. Minireview
  4. Induced human pluripotent stem cells: promises and open questions
  5. Genes and Nucleic Acids
  6. Effect of a quaternary pentamine on RNA stabilization and enzymatic methylation
  7. Protein Structure and Function
  8. A soluble form of ammonia monooxygenase in Nitrosomonas europaea
  9. Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site
  10. A dual role of the N-terminal FQQI motif in GLUT4 trafficking
  11. Molecular Medicine
  12. Peritumoral administration of GPI-anchored TIMP-1 inhibits colon carcinoma growth in Rag-2 γ chain-deficient mice
  13. Cell Biology and Signaling
  14. The effect of endogenous preproneuropeptide Y leucine 7 to proline 7 polymorphism on growth and apoptosis in primary cultured HUVECs
  15. Cross talk between kinin and angiotensin II receptors in mouse abdominal aorta
  16. Advanced glycation end product accumulation in rho0 cells without a functional respiratory chain
  17. Proteolysis
  18. Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility
  19. Catalytic properties of recombinant dipeptidyl carboxypeptidase from Escherichia coli: a comparative study with angiotensin I-converting enzyme
  20. Pharmacological inhibitors to identify roles of cathepsin K in cell-based studies: a comparison of available tools
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