RNA viruses and the mitogenic Raf/MEK/ERK signal transduction cascade
Abstract
The Raf/MEK/ERK signal transduction cascade belongs to the mitogen-activated protein kinase (MAPK) cascades. Raf/MEK/ERK signaling leads to stimulus-specific changes in gene expression, alterations in cell metabolism or induction of programmed cell death (apoptosis), and thus controls cell differentiation and proliferation. It is induced by extracellular agents, including pathogens such as RNA viruses. Many DNA viruses are known to induce cellular signaling via this pathway. As these pathogens partly use the DNA synthesis machinery for their replication, they aim to drive cells into a proliferative state. In contrast, the consequences of RNA virus-induced Raf/MEK/ERK signaling were less clear for a long time, but since the turn of the century the number of publications on this topic has rapidly increased. Research on this virus/host-interaction will broaden our understanding of its relevance in viral replication. This important control center of cellular responses is differently employed to support the replication of several important human pathogenic RNA viruses including influenza, Ebola, hepatitis C and SARS corona viruses.
©2008 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Guest Editorial
- Highlight – Viruses and Signaling
- Highlight: Viruses and Signaling
- HIV-1 at the immunological and T-lymphocytic virological synapse
- Pursuing different ‘TRADDes’: TRADD signaling induced by TNF-receptor 1 and the Epstein-Barr virus oncoprotein LMP1
- RNA viruses and the mitogenic Raf/MEK/ERK signal transduction cascade
- Hepatitis C virus (HCV) employs multiple strategies to subvert the host innate antiviral response
- Sabotage of antiviral signaling and effectors by influenza viruses
- Influenza viruses and the NF-κB signaling pathway – towards a novel concept of antiviral therapy
- Genes and Nucleic Acids
- Specific inhibition of transcriptional activity of the constitutive androstane receptor (CAR) by the splicing factor SF3a3
- Generation of synthetic RNA-based thermosensors
- Molecular Medicine
- Impaired synthesis of heme oxygenase-1 in Fanconi anemia cells can be rescued by transfection of Fanconi wild-type cDNA
- Cell Biology and Signaling
- Effects of the Cdc2-like kinase-family and DNA topoisomerase I on the alternative splicing of eNOS in TNF-α-stimulated human endothelial cells
- Proteolysis
- Cytotoxic and peptidase inhibitory activities of selected non-hepatotoxic cyclic peptides from cyanobacteria
