Molecular machinery of mitochondrial dynamics in yeast
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Abstract
Mitochondria are amazingly dynamic organelles. They continuously move along cytoskeletal tracks and frequently fuse and divide. These processes are important for maintenance of mitochondrial functions, for inheritance of the organelles upon cell division, for cellular differentiation and for apoptosis. As the machinery of mitochondrial behavior has been highly conserved during evolution, it can be studied in simple model organisms, such as yeast. During the past decade, several key components of mitochondrial dynamics have been identified and functionally characterized in Saccharomyces cerevisiae. These include the mitochondrial fusion and fission machineries and proteins required for maintenance of tubular shape and mitochondrial motility. Taken together, these findings reveal a comprehensive picture that shows the cellular processes and molecular components required for mitochondrial inheritance and morphogenesis in a simple eukaryotic cell.
©2007 by Walter de Gruyter Berlin New York
Articles in the same Issue
- To our authors, readers and subscribers ‘Just Accepted’ feature at http://www.atypon-link.com/WDG/loi/bchm
- Paper of the Year 2006: Award to Pamela Hamill
- The endosymbiotic origin of organelles: an ancient process still very much in fashion
- Solute channels of the outer membrane: from bacteria to chloroplasts
- Diverse mechanisms and machineries for import of mitochondrial proteins
- Transport of nuclear-encoded proteins into secondarily evolved plastids
- Mechanisms of protein import into thylakoids of chloroplasts
- Molecular machinery of mitochondrial dynamics in yeast
- Chloroplast photorelocation movement mediated by phototropin family proteins in green plants
- Plastid division in an evolutionary context
- Variability of the mitochondrial genome in mammals at the inter-species/intra-species boundary
- Diversity of proteasomal missions: fine tuning of the immune response
- Cellular expression of plasma prekallikrein in human tissues
- Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain
- Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes
- Cysteine protease inhibitors reduce brain β-amyloid and β-secretase activity in vivo and are potential Alzheimer's disease therapeutics
Articles in the same Issue
- To our authors, readers and subscribers ‘Just Accepted’ feature at http://www.atypon-link.com/WDG/loi/bchm
- Paper of the Year 2006: Award to Pamela Hamill
- The endosymbiotic origin of organelles: an ancient process still very much in fashion
- Solute channels of the outer membrane: from bacteria to chloroplasts
- Diverse mechanisms and machineries for import of mitochondrial proteins
- Transport of nuclear-encoded proteins into secondarily evolved plastids
- Mechanisms of protein import into thylakoids of chloroplasts
- Molecular machinery of mitochondrial dynamics in yeast
- Chloroplast photorelocation movement mediated by phototropin family proteins in green plants
- Plastid division in an evolutionary context
- Variability of the mitochondrial genome in mammals at the inter-species/intra-species boundary
- Diversity of proteasomal missions: fine tuning of the immune response
- Cellular expression of plasma prekallikrein in human tissues
- Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain
- Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes
- Cysteine protease inhibitors reduce brain β-amyloid and β-secretase activity in vivo and are potential Alzheimer's disease therapeutics
