Compartmentalised expression of meprin in small intestinal mucosa: enhanced expression in lamina propria in coeliac disease

References

Becker, C., Kruse, M.N., Slotty, K.A., Köhler, D., Harris, J.R., Rösmann, S., Sterchi, E.E., and Stöcker, W. (2003). Differences in the activation mechanism between the α and β subunits of human meprin. Biol. Chem.384, 825–831.10.1515/BC.2003.092Search in Google Scholar

Bertenshaw, G.P., Turk, B.E., Hubbard, S.J., Matters, G.L., Bylander, J.E., Crisman, J.M., Cantley, L.C., and Bond, J.S. (2001). Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity. J. Biol. Chem.276, 13248–13255.10.1074/jbc.M011414200Search in Google Scholar

Bertenshaw, G.P., Norcum, M.T., and Bond, J.S. (2003). Structure of homo- and hetero-oligomeric meprin metalloproteases. Dimers, tetramers, and high molecular mass multimers. J. Biol. Chem.278, 2522–2532.10.1074/jbc.M208808200Search in Google Scholar

Crisman, J.M., Zhang, B., Norman, L.P., and Bond, J.S. (2004). Deletion of the mouse meprin beta metalloprotease gene diminishes the ability of leukocytes to disseminate through extracellular matrix. J. Immunol.172, 4510–4519.10.4049/jimmunol.172.7.4510Search in Google Scholar

Daum, S., Bauer, U., Foss, H.D., Schuppan, D., Stein, H., Riecken, E.O., and Ullrich, R. (1999). Increased expression of mRNA for matrix metalloproteinases-1 and -3 and tissue inhibitor of metalloproteinases-1 in intestinal biopsy specimens from patients with coeliac disease. Gut44, 17–25.10.1136/gut.44.1.17Search in Google Scholar

Dumermuth, E., Sterchi, E.E., Jiang, W.P., Wolz, R.L., Bond, J.S., Flannery, A.V., and Beynon, R.J. (1991). The astacin family of metalloendopeptidases. J. Biol. Chem.266, 21381–21385.10.1016/S0021-9258(18)54648-2Search in Google Scholar

Dunnill, M.S. and Whitehead, R. (1972). A method for the quantitation of small intestinal biopsy specimens. J. Clin. Pathol.25, 243–246.10.1136/jcp.25.3.243Search in Google Scholar

Eldering, J.A., Grünberg, J., Hahn, D., Croes, H.J., Fransen, J.A., and Sterchi, E.E. (1997). Polarised expression of human intestinal N-benzoyl-l-tyrosyl-p-aminobenzoic acid hydrolase (human meprin) α and β subunits in Madin-Darby canine kidney cells. Eur. J. Biochem.247, 920–932.10.1111/j.1432-1033.1997.00920.xSearch in Google Scholar

Fais, S., Maiuri, L., Pallone, F., De Vincenzi, M., De Ritis, G., Troncone, R., and Auricchio, S. (1992). Gliadin induced changes in the expression of MHC-class II antigens by human small intestinal epithelium. Organ culture studies with coeliac disease mucosa. Gut33, 472–475.Search in Google Scholar

Grünberg, J., Dumermuth, E., Eldering, J.A., and Sterchi, E.E. (1993). Expression of the α subunit of PABA peptide hydrolase (EC 3.4.24.18) in MDCK cells. Synthesis and secretion of an enzymatically inactive homodimer. FEBS Lett.335, 376–379.Search in Google Scholar

Halstensen, T.S. and Brandtzaeg, P. (1993). Activated T lymphocytes in the celiac lesion: non-proliferative activation (CD25) of CD4⁺α/β cells in the lamina propria but proliferation (Ki- 67) of α/β and γ/δ cells in the epithelium. Eur. J. Immunol.23, 505–510.10.1002/eji.1830230231Search in Google Scholar

Henning, S.J., Oesterreicher, T.J., Osterholm, D.E., Lottaz, D., Hahn, D., and Sterchi, E.E. (1999). Meprin mRNA in rat intestine during normal and glucocorticoid-induced maturation: divergent patterns of expression of α and β subunits. FEBS Lett.462, 368–372.10.1016/S0014-5793(99)01558-6Search in Google Scholar

Herzog, C., Kaushal, G.P., and Haun, R.S. (2005). Generation of biologically active interleukin-1β by meprin B. Cytokine31, 394–403.10.1016/j.cyto.2005.06.012Search in Google Scholar

Jabri, B., de Serre, N.P., Cellier, C., Evans, K., Gache, C., Carvalho, C., Mougenot, J.F., Allez, M., Jian, R., Desreumaux, P., et al. (2000). Selective expansion of intraepithelial lymphocytes expressing the HLA-E-specific natural killer receptor CD94 in celiac disease. Gastroenterology118, 867–879.10.1016/S0016-5085(00)70173-9Search in Google Scholar

Kaushal, G.P., Walker, P.D., and Shah, S.V. (1994). An old enzyme with a new function: purification and characterization of a distinct matrix-degrading metalloproteinase in rat kidney cortex and its identification as meprin. J. Cell Biol.126, 1319–1327.10.1083/jcb.126.5.1319Search in Google Scholar

Koning, F. (2005). Celiac disease: caught between a rock and a hard place. Gastroenterology129, 1294–1301.10.1053/j.gastro.2005.07.030Search in Google Scholar

Köhler, D., Kruse, M., Stöcker, W., and Sterchi, E.E. (2000). Heterologously overexpressed, affinity-purified human meprin α is functionally active and cleaves components of the basement membrane in vitro. FEBS Lett.465, 2–7.10.1016/S0014-5793(99)01712-3Search in Google Scholar

Lahat, N., Shapiro, S., Karban, A., Gerstein, R., Kinarty, A., and Lerner, A. (1999). Cytokine profile in coeliac disease. Scand. J. Immunol.49, 441–446.10.1046/j.1365-3083.1999.00523.xSearch in Google Scholar

Lionetti, P., Breese, E., Braegger, C.P., Murch, S.H., Taylor, J., and MacDonald, T.T. (1993). T-Cell activation can induce either mucosal destruction or adaptation in cultured human fetal small intestine. Gastroenterology105, 373–381.10.1016/0016-5085(93)90710-TSearch in Google Scholar

Lottaz, D., Hahn, D., Müller, S., Müller, C., and Sterchi, E.E. (1999a). Secretion of human meprin from intestinal epithelial cells depends on differential expression of the α and β subunits. Eur. J. Biochem.259, 496–504.10.1046/j.1432-1327.1999.00071.xSearch in Google Scholar

Lottaz, D., Maurer, C.A., Hahn, D., Büchler, M.W., and Sterchi, E.E. (1999b). Nonpolarized secretion of human meprin α in colorectal cancer generates an increased proteolytic potential in the stroma. Cancer Res59, 1127–1133.Search in Google Scholar

MacDonald, T.T. and Spencer, J. (1988). Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine. J. Exp. Med.167, 1341–1349.10.1084/jem.167.4.1341Search in Google Scholar

MacDonald, T.T., Bajaj-Elliott, M., and Pender, S.L. (1999). T cells orchestrate intestinal mucosal shape and integrity. Immunol. Today20, 505–510.10.1016/S0167-5699(99)01536-4Search in Google Scholar

Marsh, M.N. (1992). Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (‘celiac sprue’). Gastroenterology102, 330–354.10.1016/0016-5085(92)91819-PSearch in Google Scholar

Monteleone, G., MacDonald, T.T., Wathen, N.C., Pallone, F., and Pender, S.L. (1999). Enhancing lamina propria Th1 cell responses with interleukin 12 produces severe tissue injury. Gastroenterology117, 1069–1077.10.1016/S0016-5085(99)70391-4Search in Google Scholar

Monteleone, G., Pender, S.L., Alstead, E., Hauer, A.C., Lionetti, P., McKenzie, C., and MacDonald, T.T. (2001a). Role of interferon α in promoting T helper cell type 1 responses in the small intestine in coeliac disease. Gut48, 425–429.10.1136/gut.48.3.425Search in Google Scholar

Monteleone, G., Pender, S.L., Wathen, N.C., and MacDonald, T.T. (2001b). Interferon-α drives T cell-mediated immunopathology in the intestine. Eur. J. Immunol.31, 2247–2255.10.1002/1521-4141(200108)31:8<2247::AID-IMMU2247>3.0.CO;2-4Search in Google Scholar

Norman, L.P., Jiang, W., Han, X., Saunders, T.L., and Bond, J.S. (2003). Targeted disruption of the meprin β gene in mice leads to underrepresentation of knockout mice and changes in renal gene expression profiles. Mol. Cell. Biol.23, 1221–1230.10.1128/MCB.23.4.1221-1230.2003Search in Google Scholar

Pender, S.L., Tickle, S.P., Docherty, A.J., Howie, D., Wathen, N.C., and MacDonald, T.T. (1997). A major role for matrix metalloproteinases in T cell injury in the gut. J. Immunol.158, 1582–1590.10.4049/jimmunol.158.4.1582Search in Google Scholar

Pischitzis, A., Hahn, D., Leuenberger, B., and Sterchi, E.E. (1999). N-Benzoyl-l-tyrosyl-p-aminobenzoic acid hydrolase β (human meprin β). A 13-amino-acid sequence is required for proteolytic processing and subsequent secretion. Eur. J. Biochem.261, 421–429.Search in Google Scholar

Salmela, M.T., Pender, S.L., Reunala, T., MacDonald, T., and Saarialho-Kere, U. (2001). Parallel expression of macrophage metalloelastase (MMP-12) in duodenal and skin lesions of patients with dermatitis herpetiformis. Gut48, 496–502.10.1136/gut.48.4.496Search in Google Scholar

Shan, L., Molberg, O., Parrot, I., Hausch, F., Filiz, F., Gray, G.M., Sollid, L.M., and Khosla, C. (2002). Structural basis for gluten intolerance in celiac sprue. Science297, 2275–2279.10.1126/science.1074129Search in Google Scholar

Shan, L., Qiao, S.W., Arentz-Hansen, H., Molberg, O., Gray, G.M., Sollid, L.M., and Khosla, C. (2005). Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue. J. Proteome Res.4, 1732–1741.10.1021/pr050173tSearch in Google Scholar

Sollid, L.M. (2002). Coeliac disease: dissecting a complex inflammatory disorder. Nat. Rev. Immunol.2, 647–655.10.1038/nri885Search in Google Scholar

Spencer, J., MacDonald, T.T., Finn, T., and Isaacson, P.G. (1986). The development of gut associated lymphoid tissue in the terminal ileum of fetal human intestine. Clin. Exp. Immunol.64, 536–543.Search in Google Scholar

Sterchi, E.E., Naim, H.Y., and Lentze, M.J. (1988a). Biosynthesis of N-benzoyl-l-tyrosyl-p-aminobenzoic acid hydrolase: disulfide-linked dimers are formed at the site of synthesis in the rough endoplasmic reticulum. Arch. Biochem. Biophys.265, 119–127.10.1016/0003-9861(88)90377-3Search in Google Scholar

Sterchi, E.E., Naim, H.Y., Lentze, M.J., Hauri, H.P., and Fransen, J.A. (1988b). N-Benzoyl-l-tyrosyl-p-aminobenzoic acid hydrolase: a metalloendopeptidase of the human intestinal microvillus membrane which degrades biologically active peptides. Arch. Biochem. Biophys.265, 105–118.10.1016/0003-9861(88)90376-1Search in Google Scholar

Walker, P.D., Kaushal, G.P., and Shah, S.V. (1998). Meprin A, the major matrix degrading enzyme in renal tubules, produces a novel nidogen fragment in vitro and in vivo. Kidney Int.53, 1673–1680.10.1046/j.1523-1755.1998.00949.xSearch in Google Scholar PubMed

Zweibaum, A., Hauri, H.P., Sterchi, E., Chantret, I., Haffen, K., Bamat, J., and Sordat, B. (1984). Immunohistological evidence, obtained with monoclonal antibodies, of small intestinal brush border hydrolases in human colon cancers and foetal colons. Int. J. Cancer34, 591–598.10.1002/ijc.2910340502Search in Google Scholar PubMed