Alternative pre-mRNA splicing in the human system: unexpected role of repetitive sequences as regulatory elements
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Jingyi Hui
and Albrecht Bindereif
Abstract
Alternative splicing is a process by which multiple messenger RNAs (mRNAs) are generated from a single pre-mRNA, resulting in functionally distinct protein products. This is accomplished by the differential recognition of splice sites in the pre-mRNA, often regulated in a tissue- or development-specific manner. Alternative splicing constitutes not only an important mechanism in controlling gene expression in humans, but also an essential source for increasing proteome diversity. In this review we summarize the underlying mechanistic principles, focussing on the cis-acting regulatory elements. In particular, the role of short sequence repeats, which are often polymorphic, in splicing regulation is discussed.
References
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©2005 by Walter de Gruyter Berlin New York
Articles in the same Issue
- Highlight: RNA Biochemistry
- microRNA-guided posttranscriptional gene regulation
- How to find small non-coding RNAs in bacteria
- Species-specific antibiotic-ribosome interactions: implications for drug development
- The tRNase Z family of proteins: physiological functions, substrate specificity and structural properties
- Alternative pre-mRNA splicing in the human system: unexpected role of repetitive sequences as regulatory elements
- 6S RNA – an ancient regulator of bacterial RNA polymerase rediscovered
- RNA thermometers are common in α- and γ-proteobacteria
- Inhibition of mRNA deadenylation and degradation by ultraviolet light
- Linear three-iron centres are unlikely cluster degradation intermediates during unfolding of iron-sulfur proteins
- Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II
- Structural properties of substrate proteins determine their proteolysis by the mitochondrial AAA+ protease Pim1
- Inhibitory plant serpins with a sequence of three glutamine residues in the reactive center
- Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of Alzheimer's disease
- Acknowledgement
- Contents Biological Chemistry Volume 386, 2005
- Author Index
- Subject Index
Articles in the same Issue
- Highlight: RNA Biochemistry
- microRNA-guided posttranscriptional gene regulation
- How to find small non-coding RNAs in bacteria
- Species-specific antibiotic-ribosome interactions: implications for drug development
- The tRNase Z family of proteins: physiological functions, substrate specificity and structural properties
- Alternative pre-mRNA splicing in the human system: unexpected role of repetitive sequences as regulatory elements
- 6S RNA – an ancient regulator of bacterial RNA polymerase rediscovered
- RNA thermometers are common in α- and γ-proteobacteria
- Inhibition of mRNA deadenylation and degradation by ultraviolet light
- Linear three-iron centres are unlikely cluster degradation intermediates during unfolding of iron-sulfur proteins
- Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II
- Structural properties of substrate proteins determine their proteolysis by the mitochondrial AAA+ protease Pim1
- Inhibitory plant serpins with a sequence of three glutamine residues in the reactive center
- Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of Alzheimer's disease
- Acknowledgement
- Contents Biological Chemistry Volume 386, 2005
- Author Index
- Subject Index