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The Magnetofection Method: Using Magnetic Force to Enhance Gene Delivery
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C. Plank
Published/Copyright:
June 1, 2005
Abstract
In order to enhance and target gene delivery we have previously established a novel method, termed magnetofection, which uses magnetic force acting on gene vectors that are associated with magnetic particles. Here we review the benefits, the mechanism and the potential of the method with regard to overcoming physical limitations to gene delivery. Magnetic particle chemistry and physics are discussed, followed by a detailed presentation of vector formulation and optimization work. While magnetofection does not necessarily improve the overall performance of any given standard gene transfer method in vitro, its major potential lies in the extraordinarily rapid and efficient transfection at low vector doses and the possibility of remotely controlled vector targeting in vivo.
:
Published Online: 2005-06-01
Published in Print: 2003-05-15
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
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- The Protease Inhibitor Bikunin, a Novel Anti-Metastatic Agent
- Transcriptional Regulation of the Urokinase Receptor (u-PAR) – A Central Molecule of Invasion and Metastasis
- Identification and Characterization of KAT, a Novel Gene Preferentially Expressed in Several Human Cancer Cell Lines
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