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Treatment of Tumor Cells with Histone Deacetylase Inhibitors Results in Altered Recruitment of Methyl-CpG Binding Proteins to a Methylated CpG Island

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Published/Copyright: June 1, 2005
Biological Chemistry
From the journal Volume 384 Issue 5

Abstract

When human cancer cells with silencing of the CDH1 gene associated with CpG island methylation and histone deacetylation were treated with histone deacetylase inhibitors, alteration in recruitment of methyl-CpG binding proteins (MBPs) to the methylated CDH1-CpG island was observed, as well as altered histone acetylation status. This change was independent of the histone deacetylase inhibitor used. These results suggest that histone hyperacetylation provides a more open chromatin structure conformation for the recruitment of additional MBPs.

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Published Online: 2005-06-01
Published in Print: 2003-05-15

Copyright © 2003 by Walter de Gruyter GmbH & Co. KG

Articles in the same Issue

  1. The Circadian Clock of the Unicellular Eukaryotic Model Organism Chlamydomonas reinhardtii
  2. Cardiovascular Control by the Suprachiasmatic Nucleus: Neural and Neuroendocrine Mechanisms in Human and Rat
  3. Synchronization of the Molecular Clockwork by Light- and Food-Related Cues in Mammals
  4. Identification of Rhythmic Subsystems in the Circadian Cycle of Crassulacean Acid Metabolism under Thermoperiodic Perturbations
  5. Age-Dependent Effects of Conditioning on Cholinergic and Vasopressin Systems in the Rat Suprachiasmatic Nucleus
  6. The Magnetofection Method: Using Magnetic Force to Enhance Gene Delivery
  7. The Protease Inhibitor Bikunin, a Novel Anti-Metastatic Agent
  8. Transcriptional Regulation of the Urokinase Receptor (u-PAR) – A Central Molecule of Invasion and Metastasis
  9. Identification and Characterization of KAT, a Novel Gene Preferentially Expressed in Several Human Cancer Cell Lines
  10. Trichostatin A and Structurally Related Histone Deacetylase Inhibitors Induce 5-Lipoxygenase Promoter Activity
  11. Treatment of Tumor Cells with Histone Deacetylase Inhibitors Results in Altered Recruitment of Methyl-CpG Binding Proteins to a Methylated CpG Island
  12. Intra- and Interspecies Interactions between Prion Proteins and Effects of Mutations and Polymorphisms
  13. Contribution of the Absolutely Conserved B8Gly to the Foldability of Insulin
  14. Fabin, a Novel Calcyon-Like and Glucanase-Like Protein with Mitogenic, Antifungal and Translation-Inhibitory Activities from Broad Beans
  15. Quantification of Elastase-Like Activity in 13 Human Cancer Cell Lines and in an Immortalized Human Epithelial Cell Line by RP-HPLC
  16. Differences in the Activation Mechanism between the α and β Subunits of Human Meprin
https://doi.org/10.1515/BC.2003.087

Articles in the same Issue

  1. The Circadian Clock of the Unicellular Eukaryotic Model Organism Chlamydomonas reinhardtii
  2. Cardiovascular Control by the Suprachiasmatic Nucleus: Neural and Neuroendocrine Mechanisms in Human and Rat
  3. Synchronization of the Molecular Clockwork by Light- and Food-Related Cues in Mammals
  4. Identification of Rhythmic Subsystems in the Circadian Cycle of Crassulacean Acid Metabolism under Thermoperiodic Perturbations
  5. Age-Dependent Effects of Conditioning on Cholinergic and Vasopressin Systems in the Rat Suprachiasmatic Nucleus
  6. The Magnetofection Method: Using Magnetic Force to Enhance Gene Delivery
  7. The Protease Inhibitor Bikunin, a Novel Anti-Metastatic Agent
  8. Transcriptional Regulation of the Urokinase Receptor (u-PAR) – A Central Molecule of Invasion and Metastasis
  9. Identification and Characterization of KAT, a Novel Gene Preferentially Expressed in Several Human Cancer Cell Lines
  10. Trichostatin A and Structurally Related Histone Deacetylase Inhibitors Induce 5-Lipoxygenase Promoter Activity
  11. Treatment of Tumor Cells with Histone Deacetylase Inhibitors Results in Altered Recruitment of Methyl-CpG Binding Proteins to a Methylated CpG Island
  12. Intra- and Interspecies Interactions between Prion Proteins and Effects of Mutations and Polymorphisms
  13. Contribution of the Absolutely Conserved B8Gly to the Foldability of Insulin
  14. Fabin, a Novel Calcyon-Like and Glucanase-Like Protein with Mitogenic, Antifungal and Translation-Inhibitory Activities from Broad Beans
  15. Quantification of Elastase-Like Activity in 13 Human Cancer Cell Lines and in an Immortalized Human Epithelial Cell Line by RP-HPLC
  16. Differences in the Activation Mechanism between the α and β Subunits of Human Meprin
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