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Hepatitis B Virus HBx Peptide 116–138 and Proteasome Activator PA28 Compete for Binding to the Proteasome α4/MC6 Subunit
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R. Stohwasser
Published/Copyright:
June 1, 2005
Abstract
PA28 is a modulator of the 20S proteasome. The PA28 binding sites on the 20S proteasome are still not well defined. Using yeast two-hybrid interaction assays and proteasome inactivation kinetics we provide evidence that the proteasome α4 subunit is one of the PA28 binding sites. This finding is supported by the observation that a hepatitis Bvirus X protein-derived polypeptide habouring the α4 proteasome subunit binding motif impairs the activation of 20S proteasomes by PA28.
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Published Online: 2005-06-01
Published in Print: 2003-01-27
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
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