New Control of Mitochondrial Membrane Potential and ROS Formation A Hypothesis
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Icksoo Lee
Abstract
A new control of mitochondrial membrane potential ΔΨm and formation of reactive oxygen species (ROS) is presented, based on allosteric ATPinhibition of cytochrome c oxidase at high intramitochondrial ATP/ADP ratios. Since the rate of ATP synthesis by the ATP synthase is already maximal at low membrane potentials (100 120 mV), the ATP/ADP ratio will also be maximal at this ΔΨm (at constant rate of ATP consumption). Therefore the control of respiration by the ATP/ADPratio keeps ΔΨm low. In contrast, the known respiratory control leads to an inhibition of respiration only at high ΔΨm values (150 200 mV) which cause ROS formation. ATPinhibition of cytochrome c oxidase is switched on and off by reversible phosphorylation (via cAMP and calcium, respectively). We propose that stress hormones which increase intracellular [Ca 2+ ] also increase ΔΨm and ROS formation, which promote degenerative diseases and accelerate aging.
Copyright © 2001 by Walter de Gruyter GmbH & Co. KG
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- Erratum
- Acknowledgement
- Content Index
- Author Index
- Subject Index
Artikel in diesem Heft
- New Control of Mitochondrial Membrane Potential and ROS Formation A Hypothesis
- Brix from Xenopus laevis and Brx1p From Yeast Define a New Family of Proteins Involved in the Biogenesis of Large Ribosomal Subunits
- Mig-6 Is a Negative Regulator of the Epidermal Growth Factor Receptor Signal
- β-Carotene Inhibits Growth of Human Colon Carcinoma Cells in Vitro by Induction of Apoptosis
- Ligand-Mediated Protection against Phage Lysis as a Positive Selection Strategy for the Enrichment of Epitopes Displayed on the Surface of E. coli Cells
- Structural and Redox Properties of the Leaderless DsbE (CcmG) Protein: Both Active-Site Cysteines of the Reduced Form Are Involved in Its Function in the Escherichia coli Periplasm
- Polyphenols of Cocoa: Inhibition of Mammalian 15-Lipoxygenase
- Total Antioxidant Capacity and Nuclear DNA Damage in Keratinocytes after Exposure to H2 O2
- Recombinant Cryptic Human Fibronectinase Cleaves Actin and Myosin: Substrate Specificity and Possible Role in Muscular Dystrophy
- Rat Tripeptidyl Peptidase I: Molecular Cloning, Functional Expression, Tissue Localization and Enzymatic Characterization
- Determination of NADH in Frozen Rat Brain Sections by Laser-Induced Fluorescence
- Human -Calpain: Simple Isolation from Erythrocytes and Characterization of Autolysis Fragments
- Erratum
- Acknowledgement
- Content Index
- Author Index
- Subject Index
