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Molecular Basis for Interactions of the DnaK Chaperone with Substrates

  • Matthias P. Mayer , Stefan Rüdiger and Bernd Bukau
Published/Copyright: July 5, 2005
Biological Chemistry
From the journal Volume 381 Issue 9-10

Abstract

Hsp70 chaperones assist a large variety of protein folding processes in the cell by transient association with short peptide segments of proteins. The substrate binding and release cycle is driven by the switching between the low affinity ATP bound state and the high affinity ADP bound state of Hsp70. Considerable progress has been made recently by the identification of in vivo substrates for the Escherichia coli homolog, DnaK, and the molecular mechanisms which govern the DnaK-substrate interactions. Here we review the processes that generate DnaK substrates in vivo and the properties of these substrates, and we describe insights gained from structural and kinetic analysis of DnaK-substrate interaction.

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Published Online: 2005-07-05
Published in Print: 2000-09-13

Copyright © 2000 by Walter de Gruyter GmbH & Co. KG

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  10. The Role of Se, Mo and Fe in the Structure and Function of Carbon Monoxide Dehydrogenase
  11. Molecular Basis for Interactions of the DnaK Chaperone with Substrates
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  13. Pathway Analysis and Metabolic Engineering in Corynebacterium glutamicum
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  23. Analysis of the Deubiquitinating Enzymes of the Yeast Saccharomyces cerevisiae
  24. Helical Tubes of FtsZ from Methanococcus jannaschii
  25. Surface Topography of Microtubule Walls Decorated with Monomeric and Dimeric Kinesin Constructs
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https://doi.org/10.1515/BC.2000.109

Articles in the same Issue

  1. Alexander J. Varshavsky Felix Hoppe-Seyler Lecturer 2000
  2. The Ubiquitin System and the N-End Rule Pathway
  3. Paper of the Year 1999: Award to Igor Stagljar
  4. A Clockwork Organ
  5. The Transgeneticists Toolbox: Novel Methods for the Targeted Modification of Eukaryotic Genomes
  6. Interdependence of Filamentous Actin and Microtubules for Asymmetric Cell Division
  7. Genetic Analysis of Mammalian Cyclin-Dependent Kinases and Their Inhibitors
  8. Phosphorylcholine Substituents in Nematodes: Structures, Occurrence and Biological Implications
  9. Selenium in Biology: Facts and Medical Perspectives
  10. The Role of Se, Mo and Fe in the Structure and Function of Carbon Monoxide Dehydrogenase
  11. Molecular Basis for Interactions of the DnaK Chaperone with Substrates
  12. Protein Import: the Hitchhikers Guide into Chloroplasts
  13. Pathway Analysis and Metabolic Engineering in Corynebacterium glutamicum
  14. Metabolic Networks: a Signal-Oriented Approach to Cellular Models
  15. Representing and Analysing Molecular and Cellular Function Using the Computer
  16. Protein Aggregation and Pathogenesis of Huntingtons Disease: Mechanisms and Correlations
  17. The Mitochondrial Protein Import Motor
  18. The Immunoglobulin κ Gene Families of Human and Mouse: a Cottage Industry Approach
  19. Protein-Protein Interactions in Receptor Activation and Intracellular Signalling
  20. Molecular Genetic Analysis of Glucocorticoid Signaling Using the Cre/loxP System
  21. Macromolecular Intelligence in Microorganisms
  22. Thyroid Hormone Receptors Bind to an Element in the Connexin43 Promoter
  23. Analysis of the Deubiquitinating Enzymes of the Yeast Saccharomyces cerevisiae
  24. Helical Tubes of FtsZ from Methanococcus jannaschii
  25. Surface Topography of Microtubule Walls Decorated with Monomeric and Dimeric Kinesin Constructs
  26. Histone Deacetylase Activity Is Required for the Induction of the MyoD Muscle Cell Lineage in Xenopus
  27. The Effect of Heat Shock on 20S/26S Proteasomes
  28. Sec61p Is the Main Ribosome Receptor in the Endoplasmic Reticulum of Saccharomyces cerevisiae
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