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Interdependence of Filamentous Actin and Microtubules for Asymmetric Cell Division
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Claudia Schaerer-Brodbeck
Published/Copyright:
July 5, 2005
Abstract
Asymmetric cell divisions are crucial to the generation of cell fate diversity. They contribute to unequal distribution of cellular factors to the daughter cells. Asymmetric divisions are characterized by a 90° rotation of the mitotic spindle. There is increasing evidence that a tight cooperation between cortical, filamentous actin and astral microtubules is indispensable for successful spindle rotation. Over the past years, the dynactin complex has emerged as a key candidate to mediate actin/microtubule interaction at the cortex. This review discusses our current understanding of how spindle rotation is accomplished by the interplay of filamentous actin and microtubules in a variety of experimental systems.
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Published Online: 2005-07-05
Published in Print: 2000-09-13
Copyright © 2000 by Walter de Gruyter GmbH & Co. KG
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- Genetic Analysis of Mammalian Cyclin-Dependent Kinases and Their Inhibitors
- Phosphorylcholine Substituents in Nematodes: Structures, Occurrence and Biological Implications
- Selenium in Biology: Facts and Medical Perspectives
- The Role of Se, Mo and Fe in the Structure and Function of Carbon Monoxide Dehydrogenase
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