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Activation of the Transcription Factor ISGF3 by Interferon-gamma
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M. Matsumoto
Published/Copyright:
June 1, 2005
Abstract
The interferon-stimulated gene factor 3 (ISGF3) transcription factor has been extensively studied in the context of the type I interferon (IFN-α/β)-mediated antiviral response; it consists of the major DNA-binding component p48, and the signal transducers and activators of transcription (Stat)1 and Stat2. We show here that type II IFN (IFN-γ) can also invoke the activation of ISGF3 in mouse primary embryonic fibroblasts. In fact, the two Stat proteins were tyrosine phosphorylated in IFN-γ stimulated cells. Our present findings reveal an additional mechanism by which these two distinct types of cytokines, IFN-α/β and -γ, can commonly elicit antiviral activities.
Published Online: 2005-6-1
Published in Print: 1999-6-1
Copyright © 1999 by Walter de Gruyter GmbH & Co. KG
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- Monoallelic Expression of Pax5: A Paradigm for the Haploinsufficiency of Mammalian Pax Genes?
- Adeno-Associated Viral Vectors for Gene Transfer and Gene Therapy
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- Dequalinium TM Vesicles Form Stable Complexes with Plasmid DNA which Are Protected from DNase Attack
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