The diversity of cellular proteinases in physiology and pathology

Kapitel in diesem Buch

1. Frontmatter I
2. Preface V
3. Intracellular proteinase of Bacillus subtilis 1509
4. Relationships between intracellular proteolytic activity and protein turnover in Bacillus megaterium 1515
5. Characterization and function of intracellular proteinases and proteinase inhibitors from yeast 1523
6. Protein degradation during the differentiation of eukaryotic cells : Studies on the sporulation of Saccharomyces cerevisiae and on the formation of the neuromuscular junction in the chick embryo 1525
7. Studies on bovine spleen cathepsin D 1531
8. Intracellular protein catabolism and new serine proteases 1537
9. Cathepsin H: An endoaminopeptidase 1547
10. The effect of human neutrophil elastase and cathepsin G on the collagen of cartilage, tendon, and cornea 1549
11. The action of cathepsin B and collagenolytic cathepsin in the degradation of collagen 1555
12. Protein cleavage in virus-infected cells 1565
13. Peptidases of the kidney microvillus membrane 1575
14. Degradation of myofibrillar proteins by cathepsins B and D 1587
15. Degradation of myones as a consequence of disuse and denervation 1605
16. The influence of immobilization on soluble proteins of muscle 1621
17. A neutral protease from rat intestinal muscle. A possible role in the degradation of native enzymes 1625
18. The susceptibility of glycogen Phosphorylase to inactivation by endogenous and exogenous proteases 1637
19. Studies on the possible physiological controls of skeletal muscle proteases 1645
20. Lysosomal enzyme secretion in rat ventral prostate. Secretagogue action of testosterone and dibutyryl cyclic AMP 1653
21. Evidence pointing to the main role of lysosomes in mitochondrial proteolysis at neutral pH 1661
22. Increased susceptibility of carbamylated glutamate dehydrogenase to proteolysis 1667
23. Acetyl glutamate — a model of signals for intracellular proteolysis 1673
24. Flow and shuttle of plasma membrane during endocytosis 1681
25. Inhibition by insulin of the physiological autophagic breakdown of cell organelles 1691
26. Proteolytic and transhydrogenolytic activities in isolated pancreatic islets of rats 1695
27. Studies on the relationship between the molecular structure and the catabolism of insulin 1705
28. Insulin and glucagon degradation in livers of sand rats (Psammomys obesus) 1713
29. Conversion of proinsulin into insulin by cathepsins B and L from rat liver lysosomes 1723
30. Presence of an endopeptidase activity in rat liver ribosomes 1729
31. Implications of amino acid compartmentation for the determination of rates of protein catabolism in livers in meal fed rats 1735
32. The role of lysosomal enzymes in protein degradation in different types of rat liver cells 1747
33. Uptake and degradation of asialo-fetuin by isolated rat hepatocytes 1753
34. Endocytosis and breakdown of proteins by sinusoidal liver cells 1763
35. The accumulation of weakly basic substances in lysosomes and the inhibition of intracellular protein degradation 1777
36. Protein degradation in isolated rat hepatocytes 1789
37. Attempts to relate enzyme inactivation to degradation in vivo 1805
38. Lysosomes and protein degradation 1815
39. Protein degradation in rat liver cells 1821
40. Intracellular protein catabolism 1823
41. Pepstatin- and leupeptin-loaded liposomes: A tool in protein breakdown studies 1829
42. Turnover of lipogenic enzymes of rat liver in dependence on age 1833
43. Aging changes in intracellular protein breakdown 1837
44. Cooperation of various subcellular fractions in protein degradation in vitro 1843
45. Pharmacological control of hyperproteolytic states in blood by enzyme inhibitors 1855
46. Biochemical and biological properties of cell and tissue neutral proteinases and inhibitors 1863
47. Naturally occurring inhibitors of intracellular proteinases 1873
48. Isolation and characterization of inhibitors of neutral proteinases from spleen 1883
49. Production of rabbit antibodies against active rat cathepsin B 1887
50. Role of heparin in the interaction of serine proteinases with antithrombin III 1893
51. Protease inhibitors produced by microorganisms 1899
52. Inhibition of glycoprotein catabolism in vivo and in the perfused rat liver 1917
53. Studies on the in vivo-action of leupeptin on the nitrogen retention in rats 1923
54. Inactivation studies of cathepsin D with diazo compounds 1927
55. Inhibition of serine proteinases by benzamidine derivatives 1931
56. Studies on some effectors of lysosomal proteinases from rat liver 1939
57. Endogenous proteolytic activity of chromatin 1945
58. Degradation of phosphorylated chromosomal nonhistone proteins 1951
59. Interaction of intracellular proteases and immune mechanisms 1955
60. The diversity of cellular proteinases in physiology and pathology 1959
61. CONTENTS/ СОДЕРЖАНИЕ/ INHALT 1970