Spectral properties of nonequilibrium states in cytochrome P-450 formed by reduction at subzero temperatures

Chapters in this book

1. Frontmatter I
2. INHALTSVERZEICHNIS VII
3. SACHWORTVERZEICHNIS XXIV
4. AUTORENVERZEICHNIS XXXI
5. Preface XXXVII
6. A thermodynamic-kinetic analysis of the cytochrome P-450 heme pocket 143
7. Cytochrome P-450Cam and putidaredoxin interaction during electron transfer 153
8. Spin state transitions of liver microsomal cytochrome P-450 163
9. Quantitative analysis of the spin equilibrium of cytochrome P-450 LM2 fraction from rabbit liver microsomes 177
10. The importance of the spin equilibrium in cytochrome P-450 for the reduction rate of the heme iron 187
11. Activated forms of oxygen in the metabolism of xenobiotics catalyzed by cytochrome P-450 201
12. Comparison of spectral properties of 3-MC induced cytochrome P-448 from rabbits and rats 207
13. Comparison of microsomal and solubilized monooxygenases from rat and rabbit by proton magnetic relaxation 217
14. Stereochemical properties of the binding site of liver microsomal cytochrome P-450 as studied by substrate analogous spin labels 235
15. Infrared spectral studies of carbon monoxide complexes of microsomal cytochromes P-450 and P-448 249
16. Isolation, structural organization and mechanism of action of mitochondrial steroid hydroxylating systems 257
17. Molecular properties of cytochrome P-45011/3 from adrenal cortex mitochondria 275
18. Model systems for the coordination chemistry of cytochrome P-450 287
19. The properties of cytochrome P-450 and hydroxylase activity of reconstituted pfoteoliposomal membranes 299
20. Pituitary control of hepatic steroid metabolism 307
21. Gas chromatography-mass spectrometry in analysis of protein amino acid composition 321
22. Isolation and characterization of cytochrome P-450meg 333
23. The alkane-hydroxylating enzyme system of the yeast Candida guilliermondii 345
24. Mercaptide chelated protoheme : A model compound for cytochrome P-450 351
25. The role of metal ions in oxygen activation 357
26. Quantum chemical interpretation of the spectral properties of the GO and Oa complexes of hemoglobin and cytochrome P-450 363
27. Catalytic properties of the liver microsomal hydroxylase system in reconstituted phospholipid vesicles 379
28. Hydrodynamic studies on interactions between the components of the liver microsomal cytochrome P-450 system 389
29. NADPH reduction of cytochrome P-450 at different integrational levels of the enzyme system 399
30. Enzymatic activities of matrix-bound components of the liver microsomal cytochrome P-450 system 409
31. Oxycytochrome P-450 : Its breakdown to superoxide for the formation of hydrogen peroxide 423
32. NADPH-dependent electron transport chain in microsomes and lipid peroxidation catalyzed by metal ions 435
33. Spectral properties of nonequilibrium states in cytochrome P-450 formed by reduction at subzero temperatures 443
34. Mechanistic studies with purified components of the liver microsomal hydroxylation system: Spectral intermediates in reaction of cytochrome P-450 with peroxy compounds 449
35. Kinetics of reduction of purified liver microsomal cytochrome P-450 in the reconstituted enzyme system studied by stopped flow spectrophotometry 459
36. Electronic and steric factors in regioselective hydroxylation catalyzed by purified cytochrome P-450 475
37. Interaction of cytochrome P-450 with hydrocarbons 483
38. Comparison of the peroxidatic activity of cytochrome P-450 with other hemoproteins and model compounds 495
39. Electrochemical investigations on the oxygen activation by cytochrome P-450 503
40. The mechanism of hydroperoxide-dependent reactions with participation of cytochrome P-450 511
41. CONTENTS 520