6.1. Introduction

Chapters in this book

1. Frontmatter I
2. Preface V
3. Contents IX
4. Chapter 1 Review of theoretical conceptions
5. 1.1. Introduction 1
6. 1.2. Classical target theory 3
7. 1.3. The LET concept 8
8. 1.4. Microdosimetry 10
9. 1.5. Gross sensitive volume with structure 19
10. 1.6. Some descriptive approaches to survival curves and RBE 25
11. Chapter 2 An approximate approach based on microdosimetry
12. 2.1. Introduction 33
13. 2.2. Formalism of the microdosimetric version of theory 34
14. 2.3. Theoretical consequences for the relative biological effectiveness 39
15. 2.4. Analysis of experimental data 46
16. 2.5. Primary lesions and the relevant RBE 53
17. 2.6. Appendix 56
18. Chapter 3 The mathematical formalism of the DNA-lesion theory of radiation action
19. 3.1. Introduction 59
20. 3.2. Prerequisites and basic principles of approximation 62
21. 3.3. Description of radiation fields 71
22. 3.4. Description of absorption events 77
23. 3.5. The model of DNA-lesion production 82
24. 3.6. The theory of cellular radiation effects 86
25. 3.7. Formal properties and consistency of the theory 93
26. 3.8. Appendix: estimation of errors 101
27. Chapter 4 The underlying physical relationships
28. 4.1. Introduction 111
29. 4.2. Linear energy transfer 112
30. 4.3. Energy spectrum of 8-rays 116
31. 4.4. Primary ionizations and ionization cluster frequencies 119
32. 4.5. Electron range 127
33. 4.6. Secondary electron spectrum of photon radiation 132
34. 4.7. Secondary charged particle spectra of fast neutrons 133
35. Chapter 5 Implications concerning microdosimetry
36. 5.1. Introduction 140
37. 5.2. The mathematical formalism 142
38. 5.3. Comparison with experimental data 151
39. Chapter 6 Evaluation of the model of DNA-lesion production
40. 6.1. Introduction 176
41. 6.2. Methodic particulars 177
42. 6.3. General results 182
43. 6.4. DNA-strand breaks 193
44. Chapter 7 Mammalian cell killing
45. 7.1. Introduction 202
46. 7.2. Survival curve analysis for monoenergetic ion radiations 206
47. 7.3. Ion radiations 217
48. 7.4. Fast neutron radiations 232
49. Chapter 8 Re-formulation of the theory
50. 8.1. Introduction 262
51. 8.2. Virtual mierodosimetry 263
52. 8.3. The ultimate general formalism of the theory of cellular radiation effects 274
53. 8.4. Evaluation of RBE in LETapproximation for monoenergetic ions 280
54. Chapter 9 Concise instructions for practical calculations
55. 9.1. Introduction 285
56. 9.2. Calculation of dose-effect relations 286
57. 9.3. Expressing a dose-effect relation by a sum of exponential functions 290
58. Appendix 297
59. References 340
60. Subject index 351