Supersensitivity to Isoprenaline in Cultured Rat Myocardial Cells Exposed to L ( + ) -Lactate and Pyruvate

Chapters in this book

1. Frontmatter 1
2. Preface 5
3. Albert Wollenberger — Scientific Humanist 7
4. Contents 9
5. I. Membranes and contractile proteins
6. Properties of Ca²⁺-ATPase in Cardiac Sarcoplasmic Reticulum 15
7. Calcium Uptake and Phosphorylation in Sarcoplasmic Reticulum: Calmodulin Effect in Cardiac Sarcoplasmic Reticulum and Stopped Flow Fluorescence Measurement of Mg · E — P in Skeletal Muscle Sarcoplasmic Reticulum 23
8. The Phosphorylation of Cardiac Contractile Proteins 29
9. Regulation of Cardiac Function During Chronic Overload. Myosin Isoenzyme Redistribution 35
10. Role of Multienzyme Complexes in Intracellular Compartmentation of Adenine Nucleotides and in Regulation of Cardiac Energy Metabolism 41
11. II. Ion movements
12. Frequency- and Voltage-Dependent Block of Sodium Channels in Single Rat Myocardial Cells Treated with Mexiletine 51
13. Pacing-dependent Properties of the Slow Inward Current in the Atrial Myocardium 57
14. Mechanical and Electrophysiological Effects of a-Adrenoceptor Stimulating Drugs in the Heart 67
15. III. Ca²⁺ transport and protein phosphorylation
16. Regulation of Intracellular Ca²⁺- Concentration in Excitable and Nonexcitable Tissues 75
17. The Regulation of the Ca²⁺ Transporting Systems of Heart Plasma Membrane 87
18. Effect of cAMP-Dependent Phosphorylation on Passive Ca²⁺ Transport in Myocardial Sarcolemma 95
19. Possible Role of Ca²⁺-ATPase in the Mechanism of Calcium Influx through Cardiac Sarcolemma 99
20. Ca²⁺-Calmodulin and Cyclic AMP-dependent Phosphorylation of Cardiac Sarcolemma 107
21. Subunit Analysis and Cross-Linking of Phospholamban in Cardiac Sarcoplasmic Reticulum and Sarcolemma 121
22. IV. Metabolic aspects of myocardial ischaemia
23. Myocardial Membrane Changes Due to Ischaemia-Reperfusion Injury in Dogs Treated With or Without Acebutolol 133
24. Free Energy of ATP-Hydrolysis as a Limiting Factor of Actin-Myosin Interaction and Ion Pumping in Early Failure of the Heart 141
25. Isoproterenol-Induced Protein Phosphorylation in the Isolated, Ischaemic Rat Heart 149
26. The Functional and Metabolic Consequence of Myocardial Ischaemia and Reperfusion. Effects of Verapamil 157
27. The Role of Calcium in Myocardial Ischaemia 169
28. The Effect of Cyclic GMP-Elevating Nitrogenous Compounds on Myocardial Glycolysis 177
29. Possible Pharmacological Measures for the Prevention of Sudden Death in Acute Local Myocardial Ischaemia 185
30. Stress Damages of the Heart: Pathogenesis, and Possibilities of Prevention and Removing 193
31. Alterations in Fatty Acyl Chain Composition of Myocardial Phospholipids During Stress 203
32. Molecular Species of Phosphatidylethanolamine in Bat and Mouse Heart 207
33. V. Communication presented as posters
34. The Effect of Hypoxia on the Structural and Enzymatic Properties of Cardiac Myosin 215
35. A Possible Role of cAMP in the Cardiotoxicity of Catecholamines During Embryonic Life 219
36. Properties and Regulation of β-Adrenoceptors in Living Cardiac Cells 221
37. Ischaemia-Induced Changes of the Cardiac Adenylate Cyclase System. I. CytQchemical Studies of Adenylate Cyclase Activity 223
38. Ischaemia-induced Changes of Cardiac Adenylate Cyclase Activity. II. Reversible Inhibition of Adenylate Cyclase 227
39. Adenylate Cyclase Activity in the Heart and Some Other Tissues Treated by a-Chymotrypsin 229
40. Supersensitivity to Isoprenaline in Cultured Rat Myocardial Cells Exposed to L ( + ) -Lactate and Pyruvate 233
41. Activation of Cyclic AMP-dependent Protein kinase in the Ischaemic Myocardium 237
42. Myocardial Protection in Vitro by o-(ß-Hydroxyethyl)-Rutoside, a Flavone Derivative and by Mannitol 241
43. Can Blood Flow Reduction after Isoproterenol Overdosage Induce Myocardial Ischaemia? 243
44. The Influence of Prostacyclin on Experimental Myocardial Infarction in Dogs 247
45. Glycogen Phosphorylase b Activity in Human Serum after Acute Myocardial Infarction and Coronary Bypass Surgery 251
46. Influence of p-Receptor Blocking Drugs on Prostacyclin and Thromboxane Synthesis 255
47. In Vivo Experiments on Phospholipid Metabolism in Rat Heart 259
48. Influence of Drugs, Hormones and Ischaemia on Glucose Uptake, CK Release and Energy Potential of Langendorff-Rabbit Hearts 263
49. Biochemieal and Electron Microscopic Findings on the Myocardium of Trained and Untrained Rats after Infarction 265
50. The Role of Altered Diabetic Coronary Reactivity in Myocardial Ischaemia 269
51. Enzyme Pattern in Endomyocardial Biopsies 275
52. Action of Tree Fatty Acids on Contractility and Action Potential of the Heart 279
53. The Influence of Ca²⁺ and Passive Tension on Relaxation Phenomena in the Mammalian Myocardium 281
54. Lipid-Diet Induced Changes of the Ca Regulation in the Babbit Myocardium 285
55. Appearances of Metabolically Influenced Long-term Vasotonus Changes in Coronary Microvessels of Rats 289
56. Potentiating Effect of Calmodulin and Cyclic AMP-Dependent Protein Kinase on the Ca²⁺-Pump of Cardiac Sarcolemma 293
57. Characterization of a Phosphorylated Protein-Lipid Complex of Heart Sarcolemma 297
58. Activation of (Ca²⁺ + Mg²⁺) ATPase oi Erythrocyte Membranes by Trypsin, Fatty Acids and Ca2/. A Comparisation with Calmodulin Action 301
59. Simultaneous Oxidation of Pyruvate and Fatty Acids by Rat-Heart Mitochondria at Limiting Substrate Supply 305
60. Protecting Effect of Adrenergic β-Blocking Agents on the Energy Metabolism of Ischaemic Myocardium 309
61. Diltiazem is a Selective Inhibitor of the Na⁺-Ca²⁺ Antiporter in Heart Mitochondria 313
62. Rest Versus Frequency Loaded Contractions in the Myocardium of Rats 319
63. Influence of Noradrenaline and Caffeine on Potentiation and Staircase Phenomena 323
64. Dissociation of Isoproterenol-Induced cAMP-Increase and Vascular Relaxation in Isolated Coronary Arteries under the Influence of DFP 327
65. Influence of Dietary Linoleate on the Adrenergic Response of Isolated Rat Hearts 329
66. Importance of Mitochondrial Creatine Kinase Localization for Securing the Stimulation of Mitochondrial ATP-Production 333
67. Metabolic Pattern in the Reperfusion Period of Different Cardiovascular Operations in the Coronary Sinus 337
68. G. GOLA,1 K. KOTHB,1 K. F. LINDENAU, A. Lurr, H . WARNKE and C. WAGENKNECHT1 341
69. List of contributors 345